World Literature on Medicinal Plants from Pankaj Oudhia’s Medicinal Plant Database -68

World Literature on Medicinal Plants from Pankaj Oudhia’s Medicinal Plant Database -68

World Literature on Medicinal Plants Quoted/Consulted/Modified/Improved/Discussed/Used/Corrected in Pankaj Oudhia’s Medicinal Plant Database.

For details please visit http://www.pankajoudhia.com

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 127. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 20 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 128. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 3 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 129. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 33 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 130. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 38 Herbs) . CGBD (Offline Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 131. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 32 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 132. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 30 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 133. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 31 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 134. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 39 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 135. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 3 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 136. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 44 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 137. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 41 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 138. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 42 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 139. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 46 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India.  Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 140. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 48 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 141. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 50 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 142. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 3 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Oudhia, P. (2009). Traditional Agricultural Knowledge in Indian state Chhattisgarh. 1.

Management of Nephotettix sp. in Rice (Oryza sativa) crop. 143. Neem (Azadirachta

indica)+ Mitragyna parviflora based formulation (With 52 Herbs) . CGBD (Offline

Database on Chhattisgarh Biodiversity), Raipur, India. 

Yamashita N & Abe T 2002 Size distribution, Growth and

Inter year variation in sex expression of  Bischofia

javanica, an Invasive Tree. Annals of Botany 90 : 599-

605.

Aswal, B. S., Bhakuni, D. S., Goel, A. K., Kar, K. and Mehrotra, B.

N.1984.  Screening of Indian Plants for Biological Activity-Part XI.

Indian J. Expt. Biol. 22: 487.

Bhinde, M. B. and Asman, R. 1963. Mechanism of action of oral

antidiabetic drugs. Indian J. Med. Res. 51: 733.

Chattopadhyay, R. R. 1999. A comparative evaluation of some blood

sugar lowering agents of plant origin. J. Ethanopharmacol. 67: 367.

Ebong, P. E., Atangwho, I. J., Eyong, E. U. and Ebong, G. E. 2008. The

Antidiabetic Efficacy of Combined Extracts from Two Continental

Plants: Azadirachta indica (A Juss)(Neem) and Vernonia amygdalina

(Del)(African Bitter leaf). American J. Biochemistry and Biotechnology.

4(3): 239-44.

Gupta, S. S. 1961. Effect of Gymnea sylvestre on adrenaline induced

hyperglycemia in rats. Indian J. Med. Sci. 15(11): 833.

Halim, E. M. 2003. Lowering of blood sugar by water extract of

Azadirachta indica and Abroma augusta in diabetic rats. Indian J. Exp.

Bio. 41: 636-640.

Kar, A., Choudhary, B. K. and Bandyopadhyay, N. G. 2003.

Comparative evaluation of hypoglycemic activity of some Indian

medicinal plants in alloxan diabetic rats. Ethnopharmacol.  84(1):

105-8.

Kirtikar, K. R. and Basu, B. D. 1991.  Indian Medicinal Plants.

Mahendra Pal Singh. pp.24-96.

Moorthy, R., Prabhu, K. M. and Murthy, P. S. 2010. Purification of

anti-hyperglycemic compound GII from fenugreek (Trigonella foenumgraecum) seeds useful in diabetes mellitus. Indian J. Exp. Biol. 48:

1111.

Noor, H. and Ashroff, S. J. 1989. Antidiabetic effects of Tinospora

crispa in rats. Ethanopharmacol. 27: 61-149.

Rathi, S. S., Grover, J. K., Vikrant, V. and Biswas, N. R. 2002.

Prevention of experimental diabetes by Indian Ayurvedic plant extracts.

Phytother. Res. 18 (8):774-7. Rege, N., Baspat, R. D., Koti, R., Desai, N. K. and Dhanurkar, S.

1993. Immunotherapy with Tinospora cordifolia a new lead in the

management of obstructive jaundice. Ind. J. Gastroenterol. 12(1):5-8.

Roman, R. R., Lara, L. A., Alarcon, A. F. and Flores Saenz, J. L. 1992.

Hypoglycemic activity of some antidiabetic plants. Arch. Med. Res.

23(3):  105-9.

Somogyi, M. 1945. A new reagent for determination of sugar. Biol.

Chem. 160: 61-68.

Stanley, M. P. and Menon, V. P. 2001. Antioxidant action of Tinospora

cordifolia root extract in alloxan diabetic rats. Phytother. Res. 15(2):

213-8.

1. Olalde Rangel JA: The systemic theory of living systems and

relevance to CAM. Evid Based Complement. Alternat Med 2005;

2(1):13-18.

2. GM Cragg; MR Boyd, R Khanna, R Kneller, TD Mays, KD Mazan,

DJ Newman, EASausville: Pure Appl. Chem 1999; 71: 1619-1633.

3. Anonymous Wealth of India: Raw materials. Vol X. New Delhi.

CSIR1976.k

4. Leyon PV, Kultan G: Effect of  Tinospora  cordifolia on the

cytokine profile of angiogenesis induced animals.  International

immunopharmacology 2004; 41569-1575.

5. Singh J, Bagla A, and Pahal V: Hepato protective activity of

herbal extracts in carbon tetrachloride intoxicated albino rats

by measuring antioxidant enzymes. International Journal of

pharm.Tech. Research 2010; 2(3):2112-2115.  

6. Prince PS, Menon: VP: Antioxidant action of  Tinospora

cordifolia roots in experimental diabetes. J of Ethanopharmacol

1999; 65:277-81.

7. Hamsa TP, Kultan GT: Tinospora cordifolia ameliorates urotoxic

effect of cyclophosphasmide by modulating GSH and cytokine

levels. Exp Toxiol pathol 2010; 1-8.

8. Treadway S: Exploring the universe of ayurvedic botanicals to

manage bacterial infections, Clinical nutrition.  Insights  1998;

6(17):1-3

9. Badara VA, Thauranet VR,Wakodic PT,Shrivastavaa

MP,Bharpura KJ,Hungorania LL,Khryaani RM: Efficiency of

Tinospora in allergic rhinitis.  Journal of Ethanopharmacolocy

2005; 96:445-449.

10. Kapur P, Jarry H, Wuttke W, Pereira BMJ, Wuttke DS: Evaluation

of antisporotic potential of Tinospora cordifolia in female rats.

Matiritas 2008; 59:329-338.

11. Warrir PK, Nambear VPK, Ramankutty C, and Nair RV: Indian

medicinal plants a compendium of 500 species 1996; 5:283.

12. Kulkarni SK: Handbook of Experimental pharmacology, 2nd

Edition, Nirali Prakashan, 2003:27-28

13. Kale SR, Kale RR: Practical pharmacology and toxicology, 6th

edition, Nirali Prakashan, 2003:27-28.

14. Bharat Gami and Farzin Parabia: Screening of methanol and

acetone extract for antimicrobial activity of some medicinal

plants species of Indian folklore,  Int.J.Res.Pharm.Sci.

2011:2(1):69-75.

Arulmozhi S, Mazumder PM, Purnima A,

Sathiya Narayanan L. 2007. In Vitro

antioxidant and Free radical scavenging

activity of Alstonia scholaris Linn. R.Br.

Iranian Journal of Pharmacology &

Therapeutics, 6: 191-196.

Atanaisu RL, Stea D, Mateescu MA, Vergely C,

Dalloz F, Briot F et al. 1998. Direct evidence

of ceruloplasmin antioxidant properties. Mol

Cell Biochem, 189: 127-135.

Aurand LW, Boone NH, Giddings GG. 1977.

Superoxide and singlet oxygen in milk lipid

peroxidation. J Dairy Sci, 60: 363-369.

Blois MS. 2001. Antioxidant activity of grape

seed extracts on peroxidation models in vitro.

J Agri Food Chem, 55: 1018.

Baynes JW. 1991. Role of oxidative stress in the

development of complications in diabetes.

Diabetes, 40: 405-12.

Chattejee IB, Nandi A. 1991. Ascorbic acid: A

scavenger of oxyradicals. Indian J Biochem

Biophys, 28: 233- 236.

Chopra K, Singh M. 1994. Involvement of

oxygen free radicals in cardioprotective effect

of rutin-A naturally occurring flavonoid.

Indian J Pharmacol, 26: 13-18.

Cotelle A, Bernier JL, Catteau JP, Pommery J,

Wallet JC, Gaydou EM. 1996. Antioxidant

properties of hydroxyl flavones. Free Rad Biol

Me, 20: 35.

Desai ID. 1984. Vitamin E analysis methods for

animal tissues. Methods Enzymol, 105:138-

147.

Dhanukar SA, Kulkarni RA, Rege NN. 2000.

Pharmacology of medicinal plants and natural

products. Indian J Pharmacol, 32: S81-S118.

Erika Szaleczky, Jozsef Prechl, Janos Feher,

Aniko Somogyi. 1999. Alterations in

enzymatic antioxidant defence in diabetes mellitus - a rational approach. Postgrad Med J,

75: 13-17.

Halliwell B, Gutteridge JM, Auroma OI. 1987.

The deoxyribose method: a simple ‘test-tube’

assay for determination of rate constants for

reactions of hydroxyl radicals. Anal.

Biochem, 165: 215-219.

Harborne JB. 1984. Phytochemical methods: A

guide to modern techniques of plant analysis.

2nd ed, pp. 85-90, Newyork, Chapman and

Hall.

Hideaki K, Yoshitaka K, Jun-ichiro M. 1999.

Beneficial effects of Antioxidants in Diabetes.

Diabetes, 48: 2398-2406.

Jay Prakash GK, Singh RP, Sakariah KK. 2000.

Antioxidant activity of grape seed extracts on

peroxidation models in vitro. J Agri Food

Chem, 55: 1018.

Kanai Mukherjee. 1989. Medical Laboratory

Technology, I

st

Edn, p. 124, New Delhi, Tata

McGraw Hill Publications.

Kannadhasan R, Venkataraman S. 2011. Blood

Glucose Concentration - A Key to Fix the

Effective Dose for Herbal Antidiabetic Drugs

using Rat Model. Inventi Rapid:

Ethnopharmacology, 2 (1): Article ID- "

Inventi:ep/257/11 " [ cited 2012 Feb 08 ] 

Available From  

http://inventi.in/Article/ep/257/11.aspx

Liu F, Ng TB. 2000. Anti oxidative and free

radical scavenging activities of selected

medicinal herbs. Life Sciences, 66: 725-735.

Marklund S, Marklund G. 1974. Involvement of

the superoxide anion radical in the autoxidation

of pyrogallol and a convenient assay for

superoxide dismutase. Eur J Biochem. 47: 469-

474.

Matkovica B. 1977. Effect of plant and animal

tissue lesions on superoxide dimutase

activities. In: Michelson A.M., J.M. McCord.,

I. Fridovich., eds. Superoxide and superoxide

dismutase. London, Academic Press. pp. 501-

515.

Matkovica B, Varga SI, Szabo L, Witas H. 1982.

The effect of diabetes on the activities of the

peroxide metabolizing enzymes. Horm Metab

Res, 14: 77-79.

Nagaraja Puranik K, Kammar KF, Devi S. 2007. 

Modulation of morphology and some

gluconeogenic enzymes activity by Tinospora cordifolia (Willd.) in diabetic rat kidney. 

Biomedical Research, 18(3): 179-183.

Okutan H, Ozcelik N, Yilmaz HR, Uz E. 2005.

Effects of caffeic acid phenethyl ester on lipid

peroxidation and antioxidant enzymes in

diabetic rat heart. Clin Biochem, 38: 191-196.

Omaye ST, Turnbull TD, Sauberlich HC. 1979.

Selected method for the determination of

ascorbic acid in animal cells tissues and

fluids. Methods Enzymol, 62: 3-11.

Ozkaya YG, Agar A, Yargicoglu P et al. 2002.

The effect of exercise on brain antioxidant

status of diabetic rats. Diabetes Metab, 28:

377-384.

Patel MB, Mishra S. 2011. Hypoglycemic

activity of alkaloidal fraction of Tinospora

cordifolia. Phytomedicine, 18: 1045-1052.

Prince PS, Kamalakkannan N, Menon VP. 2004.

Restoration of antioxidants by ethanolic

T.cordifolia in alloxan induced diabetic wistar

rats. Acta Pol Pharm, 61: 283-287.

Rajalakshmi M, Eliza J, Cecilia Edel Priya,

Nirmala A, Daisy P. 2009. Anti-diabetic

properties of  Tinospora cordifolia  stem

extracts on streptozotocin- induced diabetic

rats. African Journal of Pharmacy and

Pharmacology, 3: 171-180.

Rao MV, Rao EV. 1981. Studies on the

polysaccharide preparation (Guduchisatwa)

derived from Tinospora cordifolia. Indian J

Pharm Sci, 43:103-6.

Robert D. Hoeldtke, Kimberly D. Bryner, Daniel

R. Mc Neill. 2005. Oxidative stress and

insulin requirements in patients with recentonset type 1 diabetes. The Journal of Clinical

Endocrinology and Metabolism, 88: 1624-

1628.

Sainani GS, Manika JS, Sainani RG. 1997.

Oxidative stress- a key factor in pathogenesis

of chronic diseases. Med Update, 1:1.

Sangeetha MK, Balaji Raghavendran HR,

Gayathri V, Vasanthi HR. 2011.  Tinospora

cordifolia attenuates oxidative stress and

distorted carbohydrate metabolism in

experimentally induced type 2 diabetes in

rats. Journal of Natural Medicines, 65: 544-

550.

Senthil Kumar GP, Subramaniam S. 2007.

Evaluation of antioxidant potential of

Terminalia chebula fruits studied in Streptozotocin induced diabetic rats.

Pharmaceutical Biology, 45(6): 511-518.

Shivananjappa MM, Muralidhara. 2012.

Abrogation of maternal and fetal oxidative

stress in the streptozotocin-induced diabetic

rat by dietary supplements of Tinospora

cordifolia. Nutrition, 28: 581-587.

Sinha AK. 1972. Colorimetric assay of catalase.

Anal. Biochem, 47: 389-394.

Singh SS, Pandey SC, Srivastava S, Gupta VS,

Patro B, Ghosh AC. 2003. Chemistry and

medicinal properties of Tinospora cordifolia

(Guduchi). Indian Journal of

Pharmacology, 35: 83-91.

Soon YY, Tan BKH. 2002. Evaluation of

Hypoglycemic and Antioxidant activities of

Morinda officinalis in STZ-induced diabetic

rats. Singapore Med J, 43: 077-085.

Sreejayan N, Rao MNA. 1997. Nitric oxide

scavenging by curcuminoids. J Pharm

Pharmacol, 49:105.

Sreenivasa Reddy S, Ramatholisamma P,

Ramesh B, Baskar R, Saralakumari D. 2009. 

Beneficiary effect of tinospora cordifolia

against high-fructose diet induced

abnormalities in carbohydrate and lipid

metabolism in wistar rats. Hormone and

Metabolic Research, 41: 741-746.

Stanely Mainzen Prince, P, Padmanabhan M,

Venugopal Menon P. 2004. Restoration of

antioxidant defence by ethanolic Tinospora

cordifolia root extract in alloxan-induced

diabetic liver and kidney. Phytotherapy

Research, 18: 785-787.

Sugiura M, Ohshima M, Ogawa K, Yano M.

2006. Chronic administration of Satsuma

mandarin fruit (Citrus unshiu Marc.) improves

oxidative stress in streptozotocin-induced

diabetic rat liver. Biol Pharm Bull, 29: 588-

591.

Suryanarayana P, Satyanarayana A, Balakrishna

N, Uday Kumar P, Bhanuprakash Reddy G.

2007. Effect of turmeric and curcumin on

oxidative stress and antioxidant enzymes in

streptozotocin-induced diabetic rat. Med Sci

Monit, 13: 286-292.

Takenaka Y, Miki M, Yasuda H, Mino M. 1991.

The effect of α-tocopherol as an antioxidant

on the oxidation of membrane protein thiols

induced by free radicals generated in different

sites. Arch Biochem Biophys, 285: 344-350.

Uchiyma M, Mihara M. 1978. Determination of

Malondialdehyde precursor in tissues by

thiobarbituric acid test. Anal Biochem, 86:

271-8. 

Wohaieb SA, Godin DV. 1987. Starvationrelated alterations in free radical tissue

defense mechanisms in rats. Diabetes, 36:

169-173.

Yagi K. 1976. Simple fluorimetric assay of lipid

peroxide in blood plasma. Biochem Med, 15:

212-215. 

Yilmaz HR, Uz E, Yucel N et al. 2004. Protective

effect of caffeic acid phenethyl ester (CAPE)

on lipid peroxidation and antioxidant enzymes

in diabetic rat liver. J Biochem Mol Toxicol,

18: 234-238.

1. Verma SK and Sharma SK.  Tinospora cordifolia-A medicinal

climbing shrub propagated by stem cuttings. Arobios

Newsletter. 2003; 2(6): 35.

2. Kirtikar KP, Basu BD, Indian Medicinal Plants, 2nd ed, Vol 1, New

Connaught Place, Dehra Dun, 1975.

3. Jagetia GC, Rao SK. Evaluation of the antineoplastic activity of

guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma

bearing mice. Biol Pharm Bull. 2006; 29(3):460-6.

4. "Octacosanol". Bottom Line Monograph. 2009; 3(6):13-5. 

5. Kato S et al. Octacosanol affects lipid metabolism in rats fed on

a high-fat diet. Br J Nutr. 1995; 73(3): 433-41.

6. Stusser R, Batista J, Padron R, Sosa F, Pereztol O: Long-term

therapy with policosanol improves treadmill exercise-ECG

testing performance of coronary heart disease patients, Int J

Clin Pharmacol Ther. 1998; 36(9): 469-73.

7. Snider SR. Octacosanol in parkinsonism. Ann Neurol. 1984; 16:

723.

8. Norris F, et al.  Trial of octacosanol in amyotrophic lateral

sclerosis (ALS). Neurology. 1986; 36(9):1263-4.

9. Norris FH, et al. Nutritional supplements in amyotrophic lateral

sclerosis. Adv Exp Biol. 1987; 209:183.

10. Sarma NK, Sameksha K, Khosa RL. Alkaloids from  Tinospora

Cordifolia Miers. J. Pharm. Sci.  & Res. Vol. (1), 2009; 26-7.

1. Roy MS, Roy A, Gallucci W, Collier B, Young K. h e ovine

corticotrophin-releasing hormone-stimulation test in type

1 diabetic patients and controls: suggestion of mild chronic

hypercortisolism. Metabolism 1993; 42: 696-700.

2. Weitzman ED, Fukushima D, Nogeire C, Rof warg H, Gallagher

TF. Twenty-four hour pattern of the episodic secretion of

cortisol in normal subjects. J Clin Endocrinol Metab 1971; 33:

14-22.

3. Cameron OG, Kronfol Z, Grenden JF, Carroll BJ.

Hypothalamic-pituitary-adrenocortical activity in patients

with diabetes mellitus. Arch Gen Psychiatry 1984; 41: 1090-5.

4. Havel PJ, Hann TM, Sindelar DK, Baskin DG, Daf man

MF. Ef ects of streptozotocin-induced diabetes and insulin

treatment on the hypothalamic melanocortin system and

muscle uncoupling protein 3 expression in rats. Diabetes 2000;

49: 244-52.

5. Nadkarni AK. Indian materia medica. 3rd ed. Bombay: Popular

Prakashan; 1954. p.1221.

6. Gupta SS, Verma CL, Garg VP, Rai M. Anti-diabetic ef ects of

Tinospora cordifolia. Ef ect on fasting blood sugar level, glucose

tolerance and adrenaline-induced hyperglycem ia. Indian J

Med Res 1967; 55: 733-45.

7. Chattopadhyay SM, Ramanathan R, Das J, Bhattacharya SK.

Animal models in experimental diabetes mellitus. Indian J Exp

Biol 1997; 35: 1141-5.

8. Stanely Mainzen Prince P, Venugopal PM, Gunasekaran G.

Hypolipidaemic action of Tinospora cordifolia roots in alloxan

diabetic rats. J Ethnopharmacol 1999; 64: 53-7.

9. Trinder P. Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen. J Clin

Pathol 1969; 22: 158-61.

10. Chan O, Inouye K, Vranic M, Matthews SG. Hyperactivation

of the hypothalamo-pituitary-adrenocortical axis in

streptozotocin diabetes is associated with reduced stress

responsiveness and decreased pituitary and adrenal sensitivity.

Endocrinology 2002; 143: 1761-8.

11. Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH,

Mobbs CV. Role of glucocorticoids in mediating ef ects of

fasting and diabetes on hypothalamic gene expression. BMC

Physiol 2003; 3: 5.

12. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper’s

Biochemistry. 21st ed. Norwalk (CT): Appleton & Large; 1988.

13. Puranik N, Kammar KF, Devi S. Ei  cacy of Tinospora cordifolia

on lipid proi le in streptozotocin induced diabetic rats. Is it

benei cial to the heart? Biomed Res 2009; 25: 45-51.

14. Pushparaj P, Tan CH, Tan BKH. Ef ects of Averrhoa bilimbi leaf

extract on blood glucose and lipids in streptozotocin diabetic

rats. J Ethnopharmacol 2000; 72: 69-76.

Adedapo AA, JImoh FO, Folayan AJ, Masika PJ (2008) Antioxidant activi-

ties and phenolic contents of the methanolic extracts of the stems of

Acokanthera oppositifolia and Adenia gummifera. BMC Complement

Altern Med 8:54-60.

Agrawal A, Malini S, Bairy KL, Rao MS (2002) Effect of Tinospora cordi-

folia on learning and memory in normal and memory deÞcit rats. Indian

J Pharmacol 34:339-349.

Aher VD, Wahi A (2010) Pharmacological study of Tinospora cordifolia as an immunomodulator. Int J Curr Pharm Res 2:52-54.

Anonymous (2001) Ayurvedic Pharmacopeia of India, Part I, 1

st

 ed, vol 1.

New Delhi, India: Department of AYUSH, Ministry of Health and family

Welfare, Govt of India.

Benzie IFF, Strain JJ (1999) Ferric reducing/antioxidant power assay: Direct

measure of the total antioxidant activity of biological ßuids and modiÞ-

cation version for simultaneous measurement of total antioxidant power

and ascorbic acid concentration. Methods Enzymol 299:15-27.

Biaglow JE, Varnes ME, Epp ER, Clark EP (1987) The role of thiols in

response to radiation and drugs. In: Cerrutti PA, Nygaard OF, Simic

MG eds. Anticarcinogenesis and Radiation Protection. Plennum Press,

New York, pp. 387-397.

Bishayi B, Roychowdhury S, Ghosh S, Sengupta M (2002) Hepatoprotec-

tive and immunomodulatory properties of Tinospora cordifolia in CCl

4

intoxicated mature albino rats. J Toxicol Sci 27:139-146.

Bisset NG, Nwaiwu J (1983) Quaternary alkaloids of Tinospora species.

Planta Med 48(8):275-279.

Borchers AT, Hackman RM, Keen CL, Stern JS, Gershwin ME (1997)

Complementary medicine: A review of immunomodulatory effects of

Chinese herbal medicines. Am J Clin Nutr 66:1303-1312.

Brand-Williams W, Cuvelier M, Berset C (1995) Use of a free radical method

to evaluate antioxidant activity. Lebensm Wiss Technol 28:25-30.

Chakraborthy GS (2009) Evaluation of immunomodulatory activity of Aes-

culus indica. Int J Pharm Tech Res 1:132-134.

Chintalwar G, Jain A, Sipahimalani A, Banerji A, Sumariwalla P, Ramakrish-

nan R, Sainis K (1999) An immunologically active arabinogalactan from

Tinospora cordifolia. Phytochemistry 52(6): 1089-1093.

Fulzele SV, Satturwar PM, Joshi SB, Dorle AK (2003) Study of the immu-

nomodulatory activity of Haridradi ghrita in rats. Indian J Pharmacol

35:51-54.

Gaur K, Kori ML, Neema RK (2009) Comparative screening of immu-

nomodulatory activity of hydro-alcoholic extract of Hibiscus rosa

sinensis Linn. and ethanolic extract of Cleome gynandra Linn. Glob.

J Pharmacol 3:85-89.

Ghaisas MM, Shaikh SA, Deshpande AD (2009) Evaluation of the immu-

nomodulatory activity of ethanolic extract of the stem bark of Bauhinia

variegate L. Int J Green Pharmacol 3:70-74.

Hazra B, Biswas S, Mandal N (2008) Antioxidant and free radical scavenging

activity of Spondias pinnata. BMC Complement Altern Med 8:63-72.

Ismail S, Asad M (2009) Immunomodulatory activity of Acacia catechu.

Indian J Physiol Pharmacol 53:25-33.

Jana U, Chattopadhyay RN, Shw BP (1999) Preliminary studies on anti-

inflammatory activity of Zingiber officinale Rosc., Vitex negundo

Linn. and Tinospora cordifolia (Willd) Miers in albino rats. Indian J

Pharmacol 31:232-33.

Kapil A, Sharma S (1997) Immunopotentiating compounds from Tinospora

cordifolia. J Ethnopharmacol 58:89-95.

Kirtikar KR, Basu BD (1933) Indian Medicinal Plants. In Blatterss, Canis JR,

eds. Tinospora cordifolia. India: Lalit Mohan Publishers, pp. 77-78.

Manjrekar PN, Jolly CI, Narayanan S (2000) Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora

sinensis. Fitoterapia 71:254-257.

Mathew S, Kuttan G (1999) Immunomodulatory and antitumor activities of

Tinospora cordifolia. Fitoterapia 70: 35-43.

More P, Pai K (2011) Immunomodulatory effect of Tinospora cordifolia

(Guduchi) on macrophage activation. Bio Med 3:134-140.

Olayinka AA, Anthony IO (2010) Preliminary phytochemical screening and

in vitro antioxidant activities of the aqueous extracts of Helichrysum

longifolium DC. BMC Complement Altern Med 21:2-8.

Patel S, Banji D, Banji O, Patel MM, Shah KK (2010) Scrutinizing the

role of aqueous extract of Trapa bispinosa as an immunomodulator in

experimental animals. Int J Res Pharma Sci 1:13-19.

Patil M, Patki P, Kamath HV, Patwardhan B (1997) Anti-stress activity of

Tinospora cordifolia (Willd) Miers. Indian drugs 34:211-215.

Patwardhan B, Kalbag D, Patki PS, Nagsampagi BA (1990) Search of im-

munomodulatory agents: A review. Indian Drugs 28:56-63.

Pourmorad F, Hosseinimehr SJ, Shahabimajd N (2006) Antioxidant activity,

Phenol and ßavonoid content of some selected Iranian medicinal plants.

Afr J Biotechnol 5:1142-1145.

ShariÞfar F, Pournourmohammadi S, Arabnejad M (2009) Immunomodula-

tory activity of aqueous extract of Achillea wihelmsii C. Koch in mice.

Indian J Exp Biol 47:668-671.

Singh J, Sinha K, Sharma A, Mishra NP, Khanuja SP (2003a) Traditional

uses of Tinospora cordifolia (Guduchi). J Med Aromat Plant Sci 25:748-

751.

Singh SS, Pandy SC, Srivastava S, Gupta VS, Patro B, Ghosh AC (2003b)

Chemistry and medicinal properties of Tinospora cordifolia. Indian J

Pharmacol 35:83-91.

Sinha K, Mishra NP, Singh J, Khanuja SPS (2004) Tinospora cordifolia

(Guduchi): A reservoir plant for therapeutic applications: A review.

Indian J Trad Knowl 3:257-270.

Srinivasan GV, Unnikrishnan KP, Rema Shree AB, Balachandran I (2008)

HPLC estimation of berberin in Tinospora cordifolia and Tinospora

sinensis. Indian J Pharm Sci 70:96-99.

Tyagi S, Singh L, Devi MM, Goel HC, Rizvi MA (2009) Augmentation of

antioxidation defense system by Tinospora cordifolia: Implications in

radiation protection. J Complement Integrat Med, p.36.

Upadhyay AK, Kaushal K, Arvind K, Mishra HS (2010) Tinospora cordifolia

(Willd.) Hook. F. and Thoms. (Guduchi) - validation of the Ayurvedic

pharmacology through experimental and clinincal studies. Int J Ayurveda

Res 1:112-121.

Wade CR, Jackson PG, VanRij AM (1985) Quantitation of malondialdehyde

[MDA] in plasma, by ionpairing reverse phase high performance liquid

chromatography. Biochem Med 33:291-296.

Wesley JJ, Christina AJ, Chidambaranathan N (2008) Effect of alcoholic

extract of Tinospora cordifolia on acute and subacute inßammation.

Pharmacologyonline 3:683-687.

Zheng W, Wang SY (2001) Antioxidant activity and phenolic compounds in

selected herbs. J Agri Food Chem 49:5165-5170.

Altmann, H.J., W. Orunow, U. Mohr, H.B. Richter-Reichhelm and P.W. Wester, 1986. Effects of BHA and

related phenols on the forestomach of rats. Journal of Food Chemistry and Toxicology, 24: 1183–1188.

Ames, B.N., M.K. Shigenaga and T.M. Hagen, 1993. Oxidants, antioxidants and the degenerative diseases of

aging. In Proceedings of the National. Acad. Sci. USA, 90: 7915–7922.

AOAC, Official Methods of Analysis of AOAC International, 1996. Washington, D.C.

Babenko, N.A., Shakhova, E.G. 2006.   Effects of  Chamomilla recutita flavonoids on age-related liver

sphingolipid turnover in rats.  Experimental Gerontology,  41: 32-39.

Benzie, I.F.F., J.J. Strain, 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant

power”: the FRAP assay. Analytical Biochemistry, 239: 70.

Betancur-Ancona, D., G. Peraza-Mercado, Y. Moguel-Ordoñez and S. Fuertes-Blanco, 2004. Physicochemical

characterization of lima bean (Phaseolus lunatus) and Jack bean (Canavalia ensiformis) fibrous residues,

Journal of Food Chemistry, 84: 287–29.

Block, G., B. Patterson and A. Subar 1992. Fruits, vegetables, and cancer prevention: A review of the

epidemiological evidence, Journal of Nutrition and Cancer, 18: 1–29.

Chen, C.W. and C.T. Ho, 1994. Antioxidant properties  of polyphenols extracted from green and black teas.

Journal of Food Lipids. 251: 35-46.

Dai, F., Miao, Q., Zhou, B., Yang, L. and Liu, Z.L.  2006.   Protective effects of flavonols and their

glycosides against free radical-induced oxidative hemolysis of red blood cells.  Life Sciences, 78 : 2488-

2493.

Dimitrios, B., 2006. Sources of natural phenolic antioxidants, Trends in Food Science and Technology. 17:

505-512.

Du, Y., and Lou, H.  2008.  Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced

toxicity in cardiomyocytes.  European Journal of Pharmacology, 591: 96-101.

Halliwell, B. and J.M.C. Gutteridge, 1990. The antioxidant of human extracellular fluids. Archives of

Biochemistry and Biophysics, 280: 1-8.

Halliwell, B., 1994. Free radicals, antioxidants and human disease: Curiosity, cause, or consequence?, Lancet,

344: 721–724.

Halliwell, B. and J.M.C. Gutteridge, 1999. Free Radicals in Biology and Medicine. 3

rd

 Ed, p225. Oxford

University Press, Inc., New York.

Kongsaktrakoon, B., R. Temsiririrkkul, W. Suvitayavat, S. Nakornchai and Y. Wongkrajang, 1994. The

Antipyretic effect of  Tinospora crispa Mier ex. Hock F. & Thoms, Mahidol University, Journal of

Pharmaceutical Sciences, 21(1): 1–6.

Ledwozyw, A., Michalak, J., Stepien, A. and Kadziolka, A.  1986.  The relationship between plasma

triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis.  Clinical

Chemistry Acta.  155: 275-284.

Lu, Y.R. and F.L. Yeap, 2000. Antioxidant activities of polyphenols from sage (Salvia officinalis), Journal of

Food Chemistry, 75: 197–202.

Maisuthisakul, P., P. Sirikarn and R. Pitiporn, 2007. Relationship between antioxidant properties and chemical

composition of some Thai plants. Journal of Food Composition and Analysis, 21(3): 229-240.

McCormick, D.L., C.M. May, C.F. Thomas and C.J. Detrisac, 1986. Anticarcinogenic and hepatotoxic

interactions between retinyl acetate and butylated hydroxytoluene in rats. Cancer Research, 46: 5264–5269.

McCune, L.M. and Johns, T.  2007.  Antioxidant activity relates to plant part, life form and growing condition

in some diabetes remedies.  Journal of Ethnopharmacology, 112:  461-469.

Noor, H., P. Hammonds, R. Sutton and S.J. Ashcroft, 1989. The hypoglycaemic and insulinotropic activity of

Tinospora crispa: studies with human and rat islets and HIT-T15 cells. Diabetologia, 32: 354–359.

Noor, H. and S.J.H. Ashcroft, 1989. Antidiabetic effects of  Tinospora cripa in rats. Journal of

Ethnopharmacology, 27:149–161.

Ottolenghi, A., 1959. Interaction of ascorbic acid and  mitochondria lipids. Archives in Biochemistry and

Biophysics, 79:355.

Patel, R.P., J.B. Boersma, J.H. Crawford, N. Hogg, M. Kirk and B. Kalyanaraman, 2001. Antioxidant

mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging, Free Radical

Biology and Medicine, 31: 1570–1581.

Pathak, S.K., D.C. Jain and R.P. Sharma, 1995. Chemistry and biological activities of the Genera Tinospora,

a review, International Journal of Pharmaceutical, 33 (4): 277–287.

Ren, J., Zhao, M., Shi, J., Wang, J., Jiang, Y., Cui, C., Xue, S.  2008.  Optimization of antioxidant peptide

production from grass carp sarcoplasmic protein using response surface methodology.  Food Science and

Technology, 41: 1624-1632.

Rice-Evans, C.A. and N.J. Miller,  1996. Antioxidants: The case for fruit and vegetables in the diet. British

Journal of  Food Chemistry, 97: 35–40.

Scalzo, R.L., 2008.  Organic acids influence on DPPH

 scavenging by ascorbic acid

.  Food Chemistry, 107: 40-43.

Sanchez, M.A., S.K. Garcia, P.F. May and L.M. Pena-Rodriguez, 2001. Evaluation of biological activity of

crude extracts from plants used in Yucatecan Traditional Medicine Part I. Antioxidant, antimicrobial and

β-glucosidase inhibition activities. Phytomedicine. 8: 144.

Slater, T.F., 1991. Antioxidant, vitamins and carotene in disease prevention. American Journal of Clinical

Nutrition, 53: 189S-396S.

Tsai, T.H., P.J. Tsai and S.C. Ho, 2005. Antioxidant and anti-inflammatory activities of several commonly used

spices, Journal of Food Science, 70: 93–97.

Turkoglu, E.M. Duru, I.K. Mercan and K. Gezer, 2007. Antioxidant and antimicrobial activities of Laetiporus

sulphureus (Bull.) Murrill. Food Chemistry. 101: 267–273.

Valero, R., Lorec, A.M., Paganelli,F., Beliard, S., Atlan, C., Lairon, D., Vialettes, B. and Portugal H.  2005.

Fasting apoprotein B-48 level and coronary artery disease in a population without frank fasting

hypertriglyceridemia.  Metabolism, 54: 1442-1447.

Velioglu, Y.S., G. Mazza, L. Gao and B.D. Oomah, 1998. Antioxidant activity and total phenolics in selected

fruits, vegetables and grain products. Journal Agricultural and Food Chemistry, 46: 4113-4117.

Yen, G.C., P.D. Duh and H.L. Tsai, 2002. Antioxidant and pro-oxidant properties of ascorbic acid and gallic

acid. Journal of  Food Chemistry, 79: 307–313.

[1] Maurya R. (1996)  Regional Research Laboratory, Jammu

(CSIR), 413-442.

[2] Sharma A., Namdeo A.G. and Mahadik K.R. (2008)  Phcog. 

Rev., Pharmacognosy Review, 2(3).

[3] Ahmed S.M., Verma V., Qazi P.H., Ganaie M.M., Bakshi S.K.

and Qazi G.N. (2006) Plant Systematics and Evolution 256, 75

-87.

[4] Manjrekar P.N., Jolly C.I., Narayanan S. (2000)  Fitoterapia,

71, 254-7.

[5] Chada Y.R. (1986)  The Wealth of India-Raw materials, X,

New Delhi, CSIR.

[6] Balasubramani S.P., Murugan R., Ravikumar K., Venkatasubramanian P. (2010) Fitoterapia 81, 503-508.

[7] Yan-Bo Z., Pang-Chui S., Cho-Wing S., Zheng-Tao W., Yao T

(2007) J. Food Drug. Anal. 15, 1-9.

[8] Yip P.Y., Chau C.F., Mak C.Y., Kwan H.S. (2007) Chin. Med.

2, 93 Biotech (2011) 1, 11-19, 19, 123.

[9] Chomczynski P., Mackey K., Drews R. and Wilfinger W.

(1997) DNAzol, Bio Techniques, 22, 550-553.

[10]Doyle J.J. and Dickson E.E. (1987) Taxon 36, 715-722.

1. M. Maffei, Dietary Supplements of Plant Origin-Nutrition and Health Approach, Taylor and Francis

(2003), E-Library, 18.

2. A. B. Aliyu, A. M. Musa, M. S. Sallau and A. O. Oyewale, Proximate Composition, Mineral Elements

and Anti-nutritional Factors of Anisopus Mannii N. E. Br. (Asclepiadaceae), Trends Appl. Sci. Res.,

4(1), 68-72 (2009).

3. A. Puri, R. Saxena, R. P. Saxena, K. C. Saxena, V. Srivastava and J. S. Tandon, Immunostimulant

Agents from Andrographis Paniculata, J. Natural Prod., 56(7), 995-999 (1996). 

4. W. Tang and G. Eisenbrand, Chinese Drugs of Plant Origin, Chemistry, Pharmacology and Use in

Traditional and Modern Medicine, Springer Verlag, Berlin (1992) pp. 97-103. 

5. R. N. Chopra, S. L. Nayar and I. C. Chopra, Glossary of Indian Medicinal Plants, 1

st

 Ed., Publication

and Information Directorate, CSIR, New Delhi (1956).

6. T. F. Zhao, X. Wang, A. M. Rimando  and C. Che, Folkloric Medicinal Plants: Tinospora Sagittata

Var. Cravaniana and Mahonia Bealei, Planta Med., 57, 505 (1991).

7. Winston, David and Maimes, Steven, Adaptogens : Herbs for Strength, Stamina and Stress Relief,

Healing Arts Press (2007).

8. S. S. Singh, S. C. Pandey, S. Srivastava, V. S. Gupta, B. Patro and A. C. Ghosh, Chemistry and

Medicinal Properties of Tinospora Cordifolia (Guduchi), Indian J. Pharmacol., 35, 83-91 (2003).

9. D. Ivanova, D. Gerova, T Chervenkov and T. Yankova, Polyphenols and Antioxidant Capacity of

Bulgarian Medicinal Plants, J. Ethnopharmacol., 97(1-2), 145-150 (2005). 

10. B. Halliwell, Ascorbic Acid in the Prevention and Treatment of Cancer, Alternative Medicine Rev., 3,

174-186 (1996).

11. R. Edge, D. J. Mc Greevy and T. G. Truscott,  The Carotenoids as Antioxidants: A Review, J.

Photochem. Photobiol. B: Biol., 41, 189-200 (1997).

12. H. Y. Zhang and L. F. Wang, Theoretical Elucidation on Structure- Antioxidant Activity

Relationships for Indolinonic Hydroxylamines, Bioorganic Med. Chem. Lett., 12, 225-227 (2002). 

13. S. S. Singh, S. C. Pandey, S. Srivastava, V. S. Gupta and B. Patro, Chemistry and Medicinal

Properties of Tinospora cordifolia (Guduchi), Indian J. Pharmacol., 35, 83-91 (2003). 

14. C. P. Malick and M. B. Singh, in, Plant Enzymology and Histo Enzymology, Kalyani Publishers. New

Delhi, (1980) p. 286.

15. R. Woisky and A. Salatino, Analysis of Propils: Some Parameters and Procedure for Chemical Quality

Control, J. Agricultural Res., 37, 99-105 (1998). 

16. G. C. Yen and P. D. Duh, Antioxidative Properties of Methanolic Extracts from Peanut Hulls, J.

American Oil Chem. Soc., 70, 383-386 (1993). 

17. M. S. Blois, Antioxidant Determinations by the Use of a Stable Free Radical, Nature, 181, 1199-1200

(1958).

18. G. Cao, E. Sofic and R. L. Prior, Antioxidant and Prooxidant Behavior of Flavonoids: Structure

Activity Relationships, Free Radical Biol. Med., 22, 749-760 (1997).

19. V Bondet, W Brand-Williams and C. Berset, Kinetics and Mechanism of Antioxidant Activity Using

the DPPH Free Radical Method. Lebensmittel-Wissenschaft Technol., 30, 609-615 (1997).

20. C. A. Rice-Evans and R. Bourdon, Free Radical Lipid Interaction and their Pathological

Consequences, Progressive Lipid Res., 12, 71-110 (1993). 

21. S. Demiray, M. E. Pintado and P. M. L. Castro, Evaluation of Phenolic Profiles and Antioxidant

Activities of Turkish Medicinal Plants:  Tilia Argentea,  Crataegi Folium  Leaves and  Polygonum

Bistorta Roots, World Academy of Science, Engineering and Technol., 54, 312-317 (2009). 

22. P. G. Pietta, in, Flavonoid in Health and Disease; Rice-Evans CA, Packer L (Ed.), Marcel Dekker,

New York, (1998) p. 110. 

23. G. C. Yen and H. Y. Chen, Antioxidant Activity of Various Tea Extracts in Relation to their

Antimutagenecity, J. Agri. Food Chem., 43, 27-32 (1995). 

24. W. Brand-Williams, M. E. Cuvelier and C. Berset, Use of Free Radical Method to Evaluate

Antioxidant Activity, Lebanon Wissen Technol., 28, 25-30 (1995).

1. Begum D, Nath SC. Ethno Botanical review of medicinal plants used for skin diseases and related problems in North-East

India. J Herbs, Spices and Med Plants 2000;7:55-93.

2. Clark RA. Wound repair: an overview and general consideration. In: Clark RA, Hensen PM, eds. Molecular and Cellular

Biology of Wound Repair. New York: The Plenum Press, 1996;473-488. 

3. Pierce GF, Mustoe TA. Pharmacologic enhancement of wound healing. Ann Rev Med 1995;46:467-481. 

4. Govindachari TR. Chemical and biological investigations on Azadirachta indica (the neem tree). Current Sci 1992;3:117-

121. 

5. Kirtikar KR, Basu BD. In: Basu LM, ed. Indian Medicinal Plants, 2nd ed. Allahabad, 1935.

6. Okpanyi SN, Ezeukwu, GC. Anti-inflammatory and antipyretic activities of  Azadirachta indica. Planta Medica

1981;41:34-39.

7. Singh PP, Junnarkar AY, Reddi GS, Singh KV.  Azadirachta indica: neuro-psychopharmacological and antimicrobial

studies. Fitoterapia 1987;58:235-238.

8. Venugopal PV, Venugopal TV. Antimycotic susceptibility of dermatophytes. Indian J Med Microbiol 1993;11:151-154.

9. Dhawan BN, Patnaik GK. Neem Research and Development. In: Randhawa NS, Pannai BS, eds. India: Soc Pesticide Sci

1993;242-249.

10. Chattopadhya RR. Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Part IV. Gen

Pharmaocol 1996;27:431-434.

11. Kirtikar KR, Basu BD. Medicinal Plants. In: Blatter E, Cains JF, Mhaskar KS, eds. New Delhi: Vivek Vihar 1975;536.

12. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants, CSIR, New Delhi, 1956.

13. Mitra CR. Neem. In: Patel MS, ed. Hyderabad: Indian Central Oilseeds Committee 1963;69-94.

14. Gowrishankar R, Kumar M, Menon V, et al. Trace element studies on Tinospora cordifolia (Menispermaceae), Ocimum

sanctum (Lamiaceae),  Moringa oleifera (Moringaceae) and  Phyllanthus niruri (Euphorbiaceae) using PIXE. Biol Trace

Elem Res 2006;479:26-27.

15. Thatte UM, Rao SG, Dahanukar SA. Tinospora cordifolia induces colony stimulating activity in serum. J Postgraduate

Med 1994;40:202-203.

16. Kapil A, Sarma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95.

17. Nagarkatti DS, Rege NN, Desai NK, Dahanukar SA. Modulation of kupffer cell activity by Tinospora cordifolia in liver

damage. J Postgraduate Med 1994;40:65-67.

18. Harborne JB. Phytochemical methods-Guide to modern techniques of plant analysis, 2nd ed. Chapman and Hall India,

1991;653.

19. Bruce RD. An up-and-down procedure for acute toxicity testing. Fundam Appl Toxicol 1985;5:151-157.

20. Morton JJ, Malone MH. Evaluation of vulnerary activity by an open wound procedure in rats. Arch Int Pharmacodyn

Ther 1972;196:117-126.

21. Lee KH. Studies on mechanism of action of Salicylates II retardation of wound healing by aspirin. J Pharmacol Sci

1968;57:1042-1043.

22. Lee G, Luna HT. Manual of histological staining methods of the armed forces, Institute of Pathology, 3rd  ed. American

Registry of Pathology, The Blakiston Division, New York, Toronto, London, Sydney. 1968;68-69.

23. Snedecor GW, Cochran WG. Statistical methods, 6th ed. Iowa State University Press, Iowa,1989.

24. Gupta A, Upadhyay NK, Sawhney RC, Kumar R. A polyherbal formulation accelerated normal and impaired diabetic

wound healing. Wound Repair Reg 2008;16:784-790.

25. Udupa SL, Shetty S, Udupa AL, Somayaji SN. Effect of  Ocimum sanctum Linn. on normal and dexamethasone

suppressed wound healing. Indian J Exp Biol 2006;44:49-54.

26. Blakytny R, Jude E. The molecular biology of chronic wounds and delayed healing in diabetes. Diabetic Med

2006;2:594-608.

27. Singer AJ, Clark RA. Cutaneous wound healing. N Eng J Med 1999;341:738-746.

28. Buffoni F, Bancheli G, Cambi S, et al. Skin wound healing: some biochemical parameters in guinea pig. J Pharma

Pharmacol 1993;45:784-790.

29. Gupta A, Kumar R, Upadhyay NK, et al. Effects of  Rhodiola imbricata on dermal wound healing. Plant Med

2007;73:774-777.

1. A.F. Hill. Economic Botany. A textbook of useful

plants and plant products. 2nd edn. McGarwHill Book Company Inc, New York, (1952).

2. K.M. Nadkarni and A.K. Nadkarni, Editors.

Indian Materia Medica, Vol 1. 3rd ed. Mumbai:

M/S Popular Prakasan Pvt. Ltd, (1976).

3. K.R. Kirtikar and B.D. Basu, editors. Indian

Medicinal Plants, Vol 1. 2nd ed. New

Connaught Place, Dehra Dun: M/S Bishen Singh,

Mahendra Pal Singh, (1975).

4. R.N. Chopra, L.C. Chopra, K.D. Handa and L.D.

Kapur, Editors. Indigenous Drugs of India. 2nd

ed. Kolkata: M/S Dhar VN & Sons, (1982).

5. H. Kuroda, S.Nakazawa, K.Katagiri, O. Shiratori,

M. Konuka, K. Fujitani, and M. Tomita.

Antitumor effect of bisbenzylisoquinoline

alkaloids. Chemical and Pharmaceutical

Bulletin, 24: 2413-2420, (1976).

6. 6.R.S. Gupta, J.J. Krepinsky and L. Siminovitch.

Structural determinants responsible for the

biological activity of (−)-emetine (−)-

crytopleurine, and (−)-tylocrebrine: structureactivity relationship among related compounds.

Molecular Pharmacology 18:136, (1980).

7. D. K. Semwal, R. Badoni, R.Semwal, S. K.

Kothiyal, G. J. Preet Singh and U. Rawat. The

genus  Stephania (Menispermaceae): Chemical

and pharmacological Perspectives. Journal of

Ethnopharmacology 132 :369–383, (2010).

8. S.S. Singh, S.C. Pandey, S. Srivastava, V.S.

Gupta, B. Patro and A.C. Ghosh. Chemistry and

medicinal properties of  Tinospora cordifolia

(guduchi) Indian Journal of Pharmacology, 35:

83-91,(2003).

Etc.

[1] Bernas G,  Gonzales ER, Solevilla RC and Ysrael MC, “Pharmacology-toxicology section: a guidebook to

plant screening: phytochemical and biological”, University of Santo Tomas: Publishing House, Espana,

Manila, (2005).

[2] Candan F, et. al., “Antioxidant and  antimicrobial activity of the essential oil and methanol extracts of

Achillea millefolium subsp. Millefolium Afan.(Asteraceae)”, J. Ethnopharmacol, vol. 87, (2003), pp. 215-220.

[3] Deryugina EI and Quigley J, “Chick embryo chorioallantoic membrane models to quantify angiogenesis

induced by  inflammatory and tumor cells or purified effector molecules”, Methods Enzymol., vol. 444,

(2008), pp. 21-41.

[4] de Tavera P, “The Medicinal plants of  the Philippines. P. Blakiston’s Son and Co., (1901).

[5] Elluru SR, et. al., “Antiangiogenic  properties of viscum album extracts are associated with endothelial

cytotoxicity”, Anticancer Res., vol. 29, (2009), pp. 2945-2950.

[6] Fan TP,  Yeh JC,  Leung KW,  Yue PYK and Wong RNS, “Angiogenesis: from plants  to blood vessels”,

Trends Pharmacol Sci., vol. 27, no. 6, (2006), pp. 297-309.

[7] Folkman J, “Angiogenesis”, Annu Rev Med., vol. 57, (2006), pp. 1-8.

[8] Goze I, Cetin A and Goze A, “Investigation of effects of essential oils of Origanum minutiflorum O Schwarz

PH Davis and Cyclotrichium  niveum (Labiatae) plants on angiogenesis in shell-less chick embryo culture”,

American Journal of Biotechnology, vol. 9, no. 14, (2010) April 5, pp. 2156-2160.

[9] Keshavarz M,  Bidmeshkipour A,  Mostafaie A,  Mansouri K and M-Motiagh HR, “Anti-tumor activity of

Salvia officinalis is due to its antiangiogenic, antimigratory and antiproliferative effects”, Cell Journal, vol.

12, no. 4, (2011) Winter, pp. 477.

[10] Liu D, Liu Z, Woltering EA and Greenway FL, “Antiangiogenic effects of cucurmin in pure versus in extract

forms”, Pharm Biol., vol. 46, (2008), pp. 677-682.

[11] Madulid DA, “A pictorial cyclopedia of Philippine ornamental plants”, 2

nd

ed. Manila: Bookmark, (2000), pp.

389.       

[12] Mojzis J, Varinska L, Mojzisova G, Kostova I and Mirossay L, “Antiangiogenic effects of flavonoids and

chalcones”, Pharmacol. Res., vol. 57, (2008), pp. 259-265.

[13] Olarte EI,  “The Don Mariano Marcos  Memorial State University (DMMMSU)-potential antiangiogenic

property of Cassia alata L. hexane extract on the embryonic blood vessels of duck”, Anas domesticus

embryos, vol. 1, no. 3, ISSN No. 0119-4062, (2007) January –June.

[14] Oner FH,  Bezerra Y,  Peyman GA,  Conway M,  Lewis JM,  Liu Z,  Greenway F,  Woltering EA,

“Antiangiogneic effect of a Chinese sweet leaf extract in experimental corneal neovascularization”, Pharm.

Biol., vol. 45, (2007), pp. 46-48.

[15] Quisumbing E, “Medicinal plants of the Philippines”, Manila: Katha Publishing Co., (1978), pp. 1262.

[16] Salazar NP, Sabordo NT, Romero RC, Montalban CS, Acacio MR, Tarrayo MG, Bustos DG and Moragas

TR, “Tinospora rumphii Boerl. (Makabuhay) in the treatment of scabies”, Phil J. Microbial Infect Dis, vol.

16, no. 1, (1987), pp. 25-29.

[17] Sokmen M, Serkedjieva J, Daferera D, Gulluce M, Polissiou M, Tepe B, Akpulat A, Sahin F and Sokmen A,

“In vitro antioxidant, antimicrobial and antiviral activities of the essential oil and various extracts from

herbal parts and callus cultures of  Origanum acutidens”, J. Agric. Food Chem., vol. 52, (2004), pp. 3309-

3312.

[18] Staton CA, Lewis C and Bicknell R, “Angiogenesis assay, a critical appraisal of current techniques”, John

Wiley and Sons LTD. The Atrium, Southern Gate, Chichester, (2006).

[19] West Sussex PO19 85Q England, (1985), pp. 183-186.

[20] Stuart G,” List of medicinal plants in English and Tagalog”,

http://www.stuartxchange.org/CompleteList.html, (2000).

[21] Tepe B, Sokmen M, Sokmen A, Daferera D and Polissiou M, “Antimicrobial and antioxidative activity of the

essential oil and various extracts of Cyclotrichium origanifolium  (Labill.)”, Manden and Scheng. J. Food

Eng., vol. 69, (2005), pp. 335-342.

[22] Tufan AC and Tufan L, “The effect of ethanol exposure on extraembryonic vascular development in the chick

area vasculosa”, Cells Tissues Organs, vol. 97, (2003), pp. 175-184.

1. Amirghofran Z., Azadmehr A., Javidnia K.,

Haussknechtia elymatica: A plant with

immunomodulatory effects, Iran J Immunol., 126-31

(2007)

2. Kapur P., Pereira B.M., Wuttke W., and Jarry H.,

Androgenic action of Tinospora cordifolia ethanolic

extract    in prostate cancer Cell line LNCaP,

Phytomedicine, 16(6-7), 679-82 (2008)

3. Barthwal J., Nair S. and Kakkar P., Heavy metal

accumulation in medicinal plants collected from

environmentally different sites, Biomed Environ Sci.,

21(4), 319-24 (2008)

4. Rao S.K., Rao P.S., Rao B.N., Preliminary

investigation of  the radio-sensitizing  activity of

guduchi (Tinospora cordifolia)in tumor bearing mice ,

Phytother Res., 22(11), 1482-9 (2008)

5. Bellini M.F., Angeli J.P.F., Mutuao R., Tererzan A.P.,

Ribeiro L.R. and Mantovani M.S.,  Antigentoxicity of

Agaricus blazei mushroom organic and aqueous

extracts in chromosomal aberration ans cytokinesis

block micronucleus assays in CHO-K1 and HTC cells.

Toxicol. Vitro, 20, 355-360 (2006)

6. BN Ames , Dietary carcinogens and anticarcinogens,

Oxygen radicals and degenerative diseases, Science

221 (4617)   1256-1264 (1983)

7. Ames B.N., Profet M., and Gold L.S.,Dietary

pesticides (99.99% all natural), PNAS, 87 (19) 7777-

7781(1990)

8. Demma J, Engidawork E. and Hellman B., Potential

genotoxicity of plant extracts used in Ethiopian

traditional medicine,.  J Ethnopharmacol, 122(1),136-

42 (2009)

9. Akiyama M., Umeki S., Ksunoki Y., Kyoizumi S.,

Nakamura N., Mori T., Ishikawa Y., Yamakido M.,

Ohama K., Kodama T., Endo K. and Cologne J. B.,

Somatic Cell mutations as a possible predictor of

cancer risk, Health Phy., 68, 643-649 (1995)

10. Godec M.S., Asher D.M., Masters C.L., Kozachuk

W.E., Friedland R.P., Gibbs C.J., Jr, Gajdusek D.C.,

Rapoport S.I., and Schapiro MB. Evidence against the

transmissibility of Alzheimer's disease, , Neurology, 

41(8), 1320 (1991)

11. De Flora S., Izzotti A., Randerath K., Randerath E.,

Bartsch H., Nair J., Balansky R., van Schooten F.,

Degan P., Fronza G., Walsh D., and Lewtas J. DNA

adducts and chronic degenerative disease.

Pathogenetic relevance and implications in preventive

medicine, Mutat Res. 366(3),197-238 (1996)

12. Prescilla V.Jeurink, Cristina Lull Noguera, Huub F.J.

Savelkoul and Harry J. Wichers, Immunomodulatory

capacity of fungal proteins on the cytokine production

of human peripheral blood mononuclear cells,

International Immunopharmacology, 8(8) 1124 (2008)

13. Rao S.K., Rao P.S., and Rao B.N., Preliminary

investigation of  the radio-sensitizing  activity of

guduchi  (Tinospora cordifolia)in tumor bearing mice,

Phytother Res., 22(11), 1482-9 (2008)

14. Singh S.S., Pandey S.C., Srivastava S., Gupta V.S.,

Patro B. and Ghosh A.C., chemistry and medicinal

properties of  tinospora cordifolia  (guduchi) Indian

Journal of Pharmacology, 35, 83-91(2003)

 15. Chaudhary R., Jahan S., Goyal P.K., Chemopreventive

potential of an Indian medicinal plant (Tinospora

cordifolia) on skin carcinogenesis in mice,  J.Environ

Pathol Toxicol Oncol., 27(3), (233-43) (2008)

16. Sudhakaran D.S., Srirekha P., Devasree L.D.,

Premsingh S., and Michael R.D., Immunostimulatory

effect of  Tinospora cordifolia Miers leaf extract in

Oreochromis mossambicus,  Indian J Exp Bio., 44(9)

726-32 (2006)

17. Kamla P. Mishra, Lilly Ganju, Sudipta Chanda, Dev

Karan and Ramesh C. Sawhney, Aqueous extract of

Rhodiola imbricata Toll-like receptor-4, granzyme-B

and Th1 Cytokine in vitro Immunobiology, 214 27-31

(2009)

18. Stein G.M. and Berg P.A., Modulation of cellular and

humoral immune responses during exposure of healthy

individuals  to an Aqueous mistletoe extract,  Eur J

Med Res., 3(6) 307-14 (1998)

19. Van Der Rest B., Rolland N., Boisson A.M., Ferro M.,

Bligny R., and Douce R., Identification and

characterization of plant glycerol-phosphodiester

phosphodiesterase, Biochem. J., 379, 601–607 (2004)

20. Stich T.M., Determination of protein covalently bound

to agarose supports using bicinchoninic acid,  Anal

Biochem,  191 (2), 343-6 (1990)

21. Laemmli U. K., Cleavage of structural proteins during

the assembly of the head of bacteriophage T4, Nature,

277, 680-684 (1970)

22. Mosmann T., Rapid colorimetric assay for cellular

growth and survival: application to proliferation and

cytotoxicity assays, J.Immunol Methods,  65(1-2), 55-

63 (1983)

23. Subramanian M., Chintalwar G.J., Chattopadhyay  S.,

Antioxidant properties of a  Tinospora cordifolia

polysaccharide against iron mediated lipid damage and

gamma-ray induced protein damage,  Redox Rep., 7,

137-143 (2002)

24. Jahfar M., Glycosyl composition of polysaccharide

from Tinospora cordifolia,  Acta Pharm., 53(1), 65-9

(2003)

25.  Patwardhan B., Warude D., Pushpagandhan P., Bhatt

N., Ayurveda and  traditional Chinese medicine: a

comparative overview, Evid Based Complement

Alternat Med, 2, 465–73 (2005)

26.  Ganesh Chandra Jagetia and Shaival Kamalaksha Rao 

Evaluation of Cytotoxic Effects of Dichloromethane

Extract of Guduchi (Tinospora cordifolia Miers ex

Hook F & Thoms) on Cultured HeLa Cells, eCAM,

3(2), 267–272 (2006)

27. Ladel C.H., Blum C., Dreher A., Reifenberg K., Kopf

M. and Kaufmann S.H., Lethal tuberculosis in

interleukin-6- deficient mutant mice Infect Immun; 65,

4843-9 (1997)

28.  Anguita J., Rincon M., Samanta S., Barthold S.W.,

Flavell R.A. and Fikrig E., Borrelia burgdorferiinfected, interleukin-6-deficient mice have decreased

Th2 responses and increased lyme arthritis, J Infect

Dis,  178, 1512–5(1998)

29. Williams D.M., Grubbs B.G., Darville T., Kelly  K.

and Rank RG., A role for interleukin-6 in host defense

against murine Chlamydia trachomatis infection, Infect

Immun, 66, 4564–7 (1998)

30. Khalil A., Tullus K., Bartfai T., Bakhiet M., Jaremko

G. and Brauner A, Renal cytokine responses in acute

Escherichia coli pyelonephritis in IL-6-deficient mice,

Clin Exp Immunol, 122, 200–6 (2000)

31. Suzuki Y., Rani S. and Liesenfeld O., et al., Impaired

resistance to the development of toxoplasmic

encephalitis in interleukin-6-deficient mice,  Infect

Immun 65, 2339–45 (1997)

32. Gao W., Pereira M.A., Interleukin-6 is required for

parasite specific response and host resistance to

Trypanosoma cruzi,  Int J Parasitol,  32, 167–70

(2002)

33.  Bienz M., Dai W.J., Welle M., Gottstein B. and Muller

N., Interleukin-6- deficient mice are highly susceptible

to  Giardia lamblia infection but exhibit normal

intestinal immunoglobulin A responses against the

parasite, Infect Immun, 71,1569–73 (2003)

34. Cenci E., Mencacci A., Casagrande A., Mosci P.,

Bistoni F. and Romani L., Impaired antifungal effector

activity but not inflammatory cell recruitment in

interleukin-6-deficient mice with invasive pulmonary

aspergillosis, J Infect Dis, 184, 610–7 (2001)

35. Gallucci R.M., Simeonova P.P., Matheson J.M.,

Kommineni C., Guriel J.L., Sugawara T. and Luster

M.I., Impaired cutaneous wound healing in

interleukin-6-deficient and immunosuppressed mice,

FASEB J, (14), 2525–31 (2000)

36. Kovalovich K., DeAngelis R.A., Li W., Furth E.E.,

Ciliberto G., and Taub R., Increased toxin-induced

liver injury and fibrosis in interleukin-6- deficient

mice. Hepatology,  31,149–59(2000)

37. Lin Z.Q., Kondo T., Ishida Y., Takayasu T. and

Mukaida N., Essential involvement of IL-6 in the skin

wound-healing process as evidenced by delayed

wound healing in IL-6-deficient mice, J Leukoc Biol.,

73, 713–21 (2003)

(Contd.)