World Literature on Medicinal Plants from Pankaj Oudhia’s Medicinal Plant Database -43

World Literature on Medicinal Plants from Pankaj Oudhia’s Medicinal Plant Database -43

World Literature on Medicinal Plants Quoted/Consulted/Modified/Improved/Discussed/Used/Corrected in Pankaj Oudhia’s Medicinal Plant Database.

For details please visit http://www.pankajoudhia.com




29. Nishijima H, Uchida R, Kimiko K, Kawakami N,
Ohkuba T, Kitamura K. Mechanisms mediating the
vasorelaxing action of eugenol, pungent oil, on
rabbit arterial tissues.  Jpn J Pharmacology 1999;
79(3): 327–334.
30. Mukherji S.P. Ocimum - a cheap source of Eugenol.
Science Reporter 1987, p. 599. 31. Eugenol-rich
Ocimum variety released. In: CSIR NEWS
(Published by PID CSIR, New Delhi), 1995; 45:
256.
1. Parthasarathy R, G. Raghupati Sarma,
Janardhanan B, Padma Ramchandran, Santha T,
Sivasubramanian S. et al. Hepatic toxicity in South
Indian patients during treatment of tuberculosis
with short-course regimens containing isoniazid,
rifampicin, and pyrazinamide. Tubercle 1986; 76.
2. Speeg KV and Bay MK. Prevention and treatment
of drug induced liver disease.  Gastroenterol Clin
North Am 1995; 24: 1047–1064.
3. Singh S and Majumdar DK. Evaluation of antiinflammatory activity of fatty acids of  Ocimum
sanctum fixed oil.  Indian J Exp Biol 1997; 35(4):
380–383.
4. Gupta SK, Jaiprakash and Sushma S. Validation of
traditional claim of tulsi Ocimum sanctum Linn. as a
medicinal plant. Indian J Exp Biol 2002; 40: 765–773.
5. Agarwal P, Rai V and Singh RB. Randomized placebo
controlled, single blind trial of holy basil leaves inpatients with non insulin-dependent diabetes mellitus.
Int J Clin Pharmacol Ther 1996; 34(9): 406–409.
6. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda
C and Basu TK. Hepatoprotective activity of
ocimum sanctum leaf extract against paracetamol
induced hepatic damage in rats.  Indian J
Pharmacol 1992; 24: 163–165.
7. Bhargava KP and Singh N. Antistress activity of Ocimum
sanctum linn. Indian J Med Res 1981; 73: 443–451.
8. Ghosh MN, Fundamentals of experimental
pharmacology. Scientific book agency, Calcutta,
1984; 155.
9. Reitman S and Frankel S. In vitro determination
of transaminase activity in serum. Am J Clin Pathol
1957; 28: 56–60.
10. Doumas BT. Estimation of total protein in serum/plasma
by biuret method. Clin Chem Acta 1978; 23: 663.
11. Jendrassik L and Grof P. Quantitative estimation
of bilirubin in serum/plasma by Jendrassik and
Grof's method.  Biochem Z 1938; 29: 81.
12. Kind PRN and King EJ. Estimation of plasma
phosphatases by determination of hydrolysed
phenol with aminoantipyrine. J Clin Path 1954; 7:
322–326.
13. Davidson CS. Guidelines for detection of
hepatotoxicity due to drugs and chemicals. NIH
publication, U.S. Department of Health and
Education and Welfare NIH U.S.A. 1979.
14. Sodhi CP, Rana S, Mehta S, Vaiphei K, Goel RC,
Mehta SK. Study of oxidative stress in rifampicin
induced hepatic injury in growing rats with and
without protein energy malnutrition.  Hum Exp
Toxicol 1997; 16: 315–321.
15. Sodhi CP, Rana SV, Mehta SK, Vaiphei K, Attri S,
Thakur S et al. Study of oxidative stress in
isoniazid induced hepatic injury in young rats with
and without protein energy malnutrition.  J
Biochem Toxicol 1996; 11: 139–146.
16. Panda S and Kar A. Ocimum sanctum leaf extract
in regulation of thyroid function in male mouse.
Pharmacol Res 1998; 38(2): 107–110.
17. Gana soundari A, Devi PV and Rao MN. Modulation
of glutathione and antioxidant enzymes by Ocimum
sanctum and its role in protection against radiation
injury.  Indian J Exp Biol 1999; 37(3): 262–268.
18. Sharma P, Kulshreshtha S and Sharma AL. Anti
cataract activity of  Ocimum sanctum on
experimental cataract.  Indian J Pharmacol 1998;
30: 16–20.
19. Balanehru S and Nagarajan B. Protective effect of
oleandolic acid and ursolic acid against lipid
Peroxidation. Biochem Int 1991; 24: 981–990.
20. Liu. J. Pharmacology of oleandolic acid and ursolic
acid.  J Ethnophamacol 1995; 49: 57–68.
21. Sen P, Dewan V, Bhattacharya SK, Gupta VS,
Maiti PC and Mediratta PK. In brain and
Psychophyioslogy of stress. New Delhi, ICMR
Publication 1988; 245.
Abdulrahman F (1992). Studies in natural products: The Moraceae in
African traditional medicine and management of psychiatry in Bornu
State. M. Sc thesis, Department of Chemistry, University of Maiduguri
Chitwood DJ {2003). Phytochemical based strategies for nematode
control. Annual Review of Phytopathology 40: 221-249.
Dhawan BN, Patnik GR, Rastogy RAT, Singh KK, Tandol TS (1977).
Screening of Indian plants for biological activity. YL India Exp. B. 15:
108.
Dubey NK Tiwari TN Mandin D Andriamboavonjy H Chaumont JP
(2000). Antifungal properties of Ocimum gratissimum essential oil
(ethyl cinnamate chemotype). Fitoterapia 7(15): 567-569.
Effraim KD Jacks TW Sodipo OA (2001). Histopathological studies on
the toxicity of Ocimum gratissimum leave extract on some organs of
rabbit. Afr. J. Biomed. 6: 21-25.
Fakae BB Campbell AM Barrett J, Scott IM, Teesdale-Spittle PH,Liebau
E, Brophy PM (2000). Inhibition of glutathione-S-transferases (GSTs)
from parasitic nematodes by extracts from traditional Nigerian
medicinal plants. Phytother. Res. 1148: 630-634.
Farombi EO, Nwamkwo JO, Emerole GO (1998). Effect of methanolic
extract of browned yam flour diet on 7,12-Dimetylbenzanthracene
(DMBA) and 3-methylcholanthrene (3-MC) induced toxicity in the rat.
Proc. Fed. Afr. Soc. Biochem. Mol. Biol. 1: 5-10.
Farombi EO (2000). Mechanisms for the hepatoprotective action of
kolaviron: studies on hepatic enzymes, microsomal lipids and lipid
peroxidation in carbon tetrachloride-treated rats. Pharmacol. Res 42:
75-80.
Halliwell B, Gutteridge JMC (1992). Free radicals, antioxidants and
human diseases: where are we now? J. Lab. Clin. Med. 119:598-620.
Harborne JB (1973). Phytochemical Methods: A Guide to Modern
Technique of Plant Analysis. Chapman and Hall, London.
Hill AF (1952). Economic Botany. A textbook of useful plants and plant
products. 2 nd edn. McGraw-Hill Book Company Inc, New York.
Holets FB, Ueda-Nakamura T, Filho BPD, Cortez DAG, Morgado-Diaz
JA, Nakamura CV (2003). Effect of essential oil of Ocimum
gratissimum on the trypanosomatid Herpetomonas samuelpessoai.
Act. Protonzool 42: 269-276.
Kasaikina OT, Kortenska VD, Marinova EM, Rusina IF Yarisbheva NV
(1997). Russ. Chem. Bull. 46: 1070-1073.
Koleva II, Niederlander HAG, Van Beek TA (2000). An online HPLC
method for detection of radical scavenging compounds in complex
mixtures. Anal. Chem. 72: 2323-2328.
McDonald S, Prenzler PD, Autolovich M Robards K (2001). Phenolic
content and antioxidant activity of olive extracts. Food Chemistry, 73:
73-84.
Mensor LI, Menezes FS, Leitao GG, Reis AS, dos Santos T, Coube C
S, Leitao SG (2001). Screening of Brazillian plant extracts for
antioxidant activity by the use of DPPH free radical method.
Phytotherapy research, 15: 127-130.
Nakamura CV, Nakamura TU, Bando E, Melo AJN, Cortez DAG, Dias
Filho BP (1999). Antibacterial activity of Ocimum gratissimum
essential oil. Mem. Inst. Oswaldo Cruz 94: 675-678.
Oyaizu M, (1986). Studies on product of browning reaction prepared
from glucose amine. Japan Journal of Nutrition, 44: 307-315.
Pessoa LM, Morais SM, Bevilaqua CML, Luciano JHS (2002).
Antihelmintic activity of essential oil of Ocimum gratissimum Linn and
eugenol against Haemoachus contortus. Vet. Parasitol. 109: 59-63.
Rabelo M, Souza EP, Soares PMG, Miranda AV, Matos FJA Criddle
DN, (2003). Antinociceptive properties of the essential oil of Ocimum
gratissimumI L. (Labiatae) in ice. Bra. J. Med. Biol. Res. 36: 521-
524.
Sofowora LA (1993). Medicinal plants and traditional medicine in Africa.
Spectrum Books Ltd, Ibaban. pp. 55-71.
Sulistiarini D, Oyen LPA, Nguyen Xuan Dung (1999). Ocimum gratissimum L. In: Plant Resources of South-East Asia. No. 19: Essentialoils Plants. Prosea Foundation, Bogor, Indonesia. pp. 140-142.
Thabrew M I, Hughes RD, McFarlane IG (1998). Antioxidant activity of
Osbeckia aspera. Phytother. Res. 12: 288-290.
Trease GE, Evans WC, (1989). Trease and Evans’ Pharmacognosy: A
Physician’s Guide to Herbal Medicine. 13th Edition, Bailliere Tindall
London.
Adams RP 1995. Identification of essential oil components by gas chromatograpy/mass spectroscopy. Ilinois: USDA - Allured Publishing Corporation.        [ Links ]
Bara MTF, Vanetti MCD 1997/1998. Estudo da atividade antibacteriana de plantas medicinais, aromáticas e corantes naturais. Rev Bras Farmacogn 7/8: 21-25.        [ Links ]
Blanco MCSG, Ming LC, Marques MOM, Bovi OA 2000a. Influência da temperatura de secagem no teor e na composição química do óleo essencial de alecrim. Horticultura Brasileira 18: 903-905.        [ Links ]
Blanco MCSG, Ming LC, Marques MOM, Bovi OA 2000b. Influência da temperatura de secagem no teor e na composição química do óleo essencial de menta. Horticultura Brasileira 18: 901-903.        [ Links ]
Charles DJ, Simon JE 1990. Comparison of extraction methods for the rapid determination of essential oil content and composition of basil (Ocimum spp.). J Am Soc Hort Sci 115: 458-462.        [ Links ]
Conte CO, Laura VA, Battistelli JZ, Ceconetto AO, Solon S, Favero S 2001. Rendimento de óleo essencial de alfavaca por arraste à vapor em Clevenger, em diferentes formas de processamento das folhas. Horticultura Brasileira 19.        [ Links ]
Fleisher A 1981. Essential oils from two varieties of Ocimum basilicum L. grown in Israel. J Sci Food Agric 32: 1119-1122.        [ Links ]
Lawrence BM 1993. A planning scheme to evaluate new aromatic plants for the flavor and fragance industries. In: Janick J, Simon (eds.) New crops. New York: Wiley, p.620-627.        [ Links ]
Lorenzi H, Matos FJA 2002. Plantas medicinais no Brasil: nativas e exóticas cultivadas. Nova Odessa: Plantarum.        [ Links ]
Morales MR, Simon JE 1997. ‘Sweet Dani’: A new culinary and ornamental lemon basil. Hortscience 32: 148-149.        [ Links ]
Nagao EO, Innecco R, Mattos SH, Medeiros Filho S, Marco CA 2004. Efeito do horário de colheita sobre o teor e constituintes majoritários de óleo essencial de Lippia alba (Mill) N.E.Br., quimiotipo citral-limoneno. Ciência Agronômica 35: 355-360.         [ Links ]
Pinheiro RC, Pinto JEBP, Cardoso MG, Bertolucci SKV, Castro NEA 2002. Comparação de rendimento e qualidade dos óleos essenciais de folhas e flores de arnica e rendimento de óleos essenciais de folhas submetidas a diferentes métodos de secagem. Horticultura Brasileira 20: 1-4.        [ Links ]
Santos MRA, Innecco R 2003. Influência de períodos de secagem de folhas no óleo essencial de erva-cidreira (quimiotipo limoneno-carvona). Ciência Agronômica 34: 19-25.        [ Links ]
Simon JE 1990. Essential oils and culinary herbs. In: Janick J, Simon JE (eds) Advances in new crops. Portland: Timber Press, p.472-483.        [ Links ]
1. Madeira SVF, Matos FJA, Leal-Cardoso JH & Criddle DN (2002). Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea-pig. Journal of Ethnopharmacology, 81: 1-4.        [ Links ]
2. Matos FJA (1998). Farmácias vivas: sistema de utilizacão de plantas medicinais projetado para pequenas comunidades. EUFC, Fortaleza, CE, Brazil, 220.        [ Links ]
3. Oliver B (1960). Medicinal Plants in Nigeria. Nigerian College of Arts. Science and Technology, Ibadan, Nigeria, 42.        [ Links ]
4. Aziba PI, Bass D & Elegbe Y (1999). Pharmacological investigation of Ocimum gratissimum in rodents. Phytotherapy Research, 13: 427-429.        [ Links ]
5. Calixto JB, Beirith A, Ferreira J, Santos ARS, Cechinel Filho V & Yunes RA (2000). Naturally ocurring antinociceptive substances from plants. Phytotherapy Research, 14: 401-418.        [ Links ]
6. Koster R, Anderson M & Debeer EJ (1959). Acetic-acid for analgesic screening. Federation Proceedings, 18: 412.        [ Links ]
7. Huskaar S, Fasmer OB & Hole K (1985). Formalin test in mice, a useful technique for evaluating mild analgesics. Journal of Neuroscience Methods, 14: 69-76.        [ Links ]
8. Rosland JH, Tjolsen A, Maehle B & Hole K (1990). The formalin test in mice: effect of formalin concentration. Pain, 42: 235-242.        [ Links ]
9. Siegmund E, Cadmus R & Lu G (1957). A method for evaluating both non-narcotic and narcotic analgesics. Proceedings of the Society for Experimental Biology and Medicine, 95: 729-731.        [ Links ]
10. Berkenkopf JW & Weichman BM (1988). Production of prostacyclin in mice following intraperitoneal injection of acetic-acid, phenylbenzoquinone and zymosan: its role in the writhing response. Prostaglandins, 36: 693-709.        [ Links ]
11. Le Bars D, Gazariu M & Cadden SW (2001). Animal models of nociception. Pharmacological Reviews, 53: 597-652.        [ Links ]
12. Dickenson AH & Sullivan AF (1987). Subcutaneous formalin induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administrated pre or post-formalin. Pain, 30: 349-360.        [ Links ]
13. Malmberg AB & Yaksh TL (1995). Antinociceptive actions of spinal nonsteroidal antiinflammatory agents on the formalin test in the rat. Journal of Pharmacology and Experimental Therapeutics, 263: 136-146.        [ Links ]
14. Shibata T, Ohkubo T, Tsuruda K & Takahashi H (1994). Mode of analgesic action of phenolic dental medicaments through substance P release. Japanese Journal of Oral Biology, 36: 49-59.        [ Links ]
15. Du Plooy WJ, Swart L & Huysteen GW (2001). Poisoning with Boophane disticha: a forensic case. Human and Experimental Toxicology, 20: 277-278.        [ Links ]
16. Brodin P (1985). Differential inhibition of A, B and C fibers in the rat vagus nerve by lidocaine, eugenol and formaldehyde. Archives of Oral Biology, 30: 477-480.        [ Links ]
17. Hirafuji M (1984). Inhibition of prostaglandin I2 biosynthesis in rat dental pulp by phenolic dental medicaments. Japanese Journal of Pharmacology, 36: 544-546.        [ Links ]
18. Dohi T, Anamura S, Shirakawa M, Okamoto H & Tsujimoto A (1991). Inhibition of lipoxygenase by phenolic compounds. Japanese Journal of Pharmacology, 55: 547-550.        [ Links ]
19. Patacchini R, Maggi CA & Meli A (1990). Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn-Schmiedeberg's Archives of Pharmacology, 342: 72-77.        [ Links ]
20. Santos FA & Rao VS (2000). Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytotherapy Research, 14: 240-244.        [ Links ]
            Kiritikar K R Basu, B. D. Indian Medicinal Plants, Vol. III, pp.1965, Delhi, Periodical Experts Book Agency, 1975.     
2.         Chopra R N, Chopra I C, Handa K L, Kapur L D. Chopra's indigenous drugs of India, pp. 580, 608, 610, 680, 816, Calcutta, UN Dhar & Sons Pvt. Ltd., 1958.     
3.         3. Nadakarni A. K. India Materia Medica, vol.1, pp. 865, Bombay, Popular Book  Depot, 1954.     
4.         Joshi CG, Magar N G Antibiotic activity of Indian Medicinal Plants, J Sci Ind Res 1952; 11B : 261 -263.     
5.         Gupta K C, Vishwanathan. R. A short note on antitubercular substances from Ocimum sanctrum, Antibiotic Chemother. 1955 ; 25 : 22 - 23     
6.         Grover, G. S Rao. Investigations of antimicroobial efficiency from essential oil from O. sanctum & O. gratissimum. Perfuma, Kosmat, 1977, 58: 326 - 329.     
7.         Godhwani S, Godhwani JL, Vyas DS. Ocimum sanctum - an experimental study evaluating its antiinflammatory, analgesic and antipyretic activity in animals. J Ethanopharmacol. 1987 ; 21 : 153 - 163.     
8.         Uma Devi P, Ganasoundari A. Radioprotective effect of leaf extract of Indian Medicinal Plant O. sanctum. Indian J Exptl Biol 1995 ; 33: 205 - 208.     
9.         Suffness M, Douros J. Methods in cancer research, vol. 116, pp. 73, New York, Academic Press, 1979.     
10.       Lucy Treagan. Medical Micro - biology - Lab Procedures, pp. 233, Philadelphia, W.B. Saunders Company, 1982.     
11.       Cruick Shank R, Duguid JP. Manoin BP, Swain RHA. The Practice of Medical Microbiology vol. 11, pp. 196, London, Churchill Livingstone, 1975.     
12.       WHO 5 th programme report 1984 - 1985 : Programme for control of diarrhoeal diseases, Geneva, Bulletin of WHO 1985; 63 : 757 - 772.     
13.       Morankar SN. Childhood diarrhoea management, pp. 123, Pune, Dastane Ramachandra and Co., 1998. 
1. Charles, D. J.; Simon, J. E.; J. Am. Soc. Hort. Sci. 1990, 115, 458.        [ Links ]
2. Simon, J. E.; Quinn, J.; Murray, R.G. In Advances in New Crops; Janick, J.; Simon, J.E., eds., Timber Press: Portland, OR, 1990, p. 484-489.        [ Links ]
3. Lachowicz, K. J.; Jones, G. P.; Briggs, D. R.; Bienvenu, F. E.; Palmer, M. V.; Ting, S. S.; Hunter, M. ; J. Agric. Food Chem. 1996, 44, 877.        [ Links ]
4. Lachowicz, K. J.; Jones, G. P.; Briggs, D. R.; Bienvenu, F. E.; Palmer, M. V.; Mishra, V.; Hunter, M. ; J. Agric. Food Chem. 1997, 45, 2660.        [ Links ]
5. Venskutonis, R.; Poll, L.; Larsen, M. ; Flavour Fragr. J. 1996, 11,117.        [ Links ]
6. Grayer, R. J.; Bryan, S. E.; Veitch, N. C.; Goldstone, F. J.; Paton, A.; Wollenweber, E.; Phytochemistry 1996, 43, 1041.        [ Links ]
7. Fleisher, A. ; J. Sci. Food Agric. 1981, 32, 11.        [ Links ]
8. Lawrence, B. M.; A World Perspective. Proceedings of the 10 th International Congress of Essential Oils, Fragrances and Flavors, Washington, DC, USA 1986, Elsevier Science Publisher B.V. : Amsterdam, 1988, p. 161.        [ Links ]
9. Marotti, M.; Piccaglia, R.; Giovanelli, E.; J. Agric. Food Chem. 1996, 44, 3926.        [ Links ]
10. Sanda, K.; Koba, K.; Nambo, P.; Gaset, A.; Flavour Fragr. J. 1998, 13, 226.        [ Links ]
11. Yusuf, M.; Begum, J.; Mondello, L.; Stagno d´ Alcontres, I.; Flavour Fragr. J. 1998, 13, 163.        [ Links ]
12. Ravid, U.; Putievsky, E.; Katzir, I.; Lewinsohn, E.; Flavour Fragr. J. 1997, 12, 293.        [ Links ]
13. Hasegawa, Y.; Tajima, K.; Toi, N.; Sugimura, Y.; Flavour Fragr. J. 1997, 12, 195.        [ Links ]
14. Lawrence, B. M.; Perf. Flav. 1989, 14, 45.        [ Links ]
15. Lawrence, B. M.; Proceedings of the 11th International Congress of Essential Oils, Fragrance and Flavors, New Delhi, India, 1989.        [ Links ]
16. Murillo, E.; Viña, A.; Rev. Col. Quim. 1999, 28, 65.        [ Links ]
17. Grayer, R. J.; Kite, G. C.; Goldstone, F. J.; Bryan, S. E.; Paton, A.; Putievsky, E.; Phytochemistry 1996, 43, 1033.        [ Links ]
18. Lawrence, B. M.; Perf. Flav. 1995, 20, 35.        [ Links ]
19. Pushpangadan, P.; Bradu, B. L. In Advances in Horticulture. Medicinal and Aromatic Plantas; Chadha, K. L. Gupta, R., eds.; Malhotra Publishing House: New Delhi, India, 1995, vol. 11, p. 627.        [ Links ]
20. Moreno, B. G. V.; Tamayo, C. C. H.; Estrada, E. I.; Acta Agronómica, Universidad Nacional de Colombia 1987, 37, 34.        [ Links ]
21. European Pharmacopoeia, 2nd ed., Maisonneuve S.A.: Sainte Ruffin, France, 1980.        [ Links ]
22. Adams, R. P.; Identification of Essential Oil Components by Gas Chromatography - Mass Spectroscopy, Allured Publishing Corporation: Carol Stream, IL, USA, 1995.        [ Links ]
23. Kondjoyan, N.; Berdagué, J-L.; A Compilation of Relative Retention Indices for the Analysis of Aromatic Compounds, Edition du Laboratoire Flaveur: France, 1996.        [ Links ]
1. Sobti, S.N.; Pushpangandan, P. In Cul ti va tion and Uti li za -
tion of Ar o matic Plants; Atal, C.K.; Kapur, B.M., Ed.; Regional Re search Lab; Jammu-Tawi  In dia,1982,  v 03, p
457-472.
2. Guenther, E. In The Es sen tial Oils; R. Krieger; New York,
1972. v 1.
3. Vanderlinde, F.A. et al. In XII Simpósio de Plantas
Medicinais do Brasil; UFCE; Fortaleza, 1994, p 156.
4. Pouchert, C.J. In The Aldrich Chem i cal of In fra red Spec tra;
Aldrich Chem i cal; Mil wau kee, 1981.
5. Rizk, A.M.; Al-Nowaihi, A.S. In The Phytochemistry of the
Hor ti cul tural Plants of Qa tar; Alden Press; Ox ford-UK,
1989.
6. Franz, C. In Vol a tile Oil Crops: Their Bi ol ogy, Bio chem is -
try; Hay, R.K.M; Water man, P.G., Ed.; Longmam Sci en -
tific & Tech ni cal; Bath, 1993, p 63.
7. Col lins, C.H.; Braga, G.L.; Bonato, P.S. In Introdução a
Métodos Cromatográficos; UNICAMP; Campinas, 1990.
8. Nayak, U.G.; Guha, P.C.In dian Chem. Soc. 1952, 29, 112.
9. Khorana, M.L.; Vangikan, M.B. In dian J. Pharm. 1983, 12,
132.
10. Ribeiro, R.C.L.F.; Giulietti, A.M.; Barradas, M.M.;
Salatino, A. Anais da Ac a de mia Brasileira de Ciências
1972, 44, p 65-71.
11. Gupta, R. In G-15 Gene Banks for Me dic i nal and Ar o matic
Plants News let ter No.5; Cenargen/EMBRAPA; Bra si lia,
1994.
            Seeman P, Corbett R, Nam D, Van Tol HH. Dopamine and serotonin receptors: Amino acid sequences and clinical role in neuroleptic parkinsonism. Jpn J Pharmacol 1996;71:187-204.    [PUBMED]  [FULLTEXT]
2.         Casey DE. Tardive dyskinesia: Pathophysiology and animal models. J Clin Psychiat 2000;61:5-9.     
3.         Kulkarni SK, Naidu PS. Tardive dyskinesia: An update. Drugs Today 2001;37:97-119.    [PUBMED]  [FULLTEXT]
4.         Silva SR, Futuro-Neto HA, Pires JG. Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice. Neuropharmacology 1995;34:97-9.    [PUBMED]  [FULLTEXT]
5.         Pires JG, Costa PG, Saraiva FP, Bonikovski V, Futuro Neto HA. Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice. Braz J Med Biol Res 2003;36:239-45.    [PUBMED]  [FULLTEXT]
6.         Somani RS, Kasture VS, Kasture SB. Haloperidol inhibits (-) bicucullin induced seizures and bicucullin potentiates haloperidol induced catalepsy in mice. Indian J Pharmacol 1999;31:434-6.     
7.         Klemm WR. Evidence for a cholinergic role in haloperidol-induced catalepsy. Psychopharmacology (Berl) 1985;85:139-42.    [PUBMED] 
8.         Gupta SK, Prakash J, Srivastava S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Expt Biol 2002;40:765-73.     
9.         Liu J. Pharmacology of oleanolic and ursolic acid. J Ethnopharmacol 1995;49:57-68.    [PUBMED]  [FULLTEXT]
10.       Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psycho - pharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50.     [PUBMED]  [FULLTEXT]
11.       Ravindran R, Rathinasamy SD, Samson J, Senthilvelan M. Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats. J Pharmacol Sci 2005;98:354-60.    [PUBMED]  [FULLTEXT]
12.       Chakradhara Rao, Lalith M, Gopalakrishna HN. The effect of NR-ANX-C (a polyherbal product) on HIC. Indian J Physiol Pharmacol 2004;48:108-9.     
13.       Ferre S, Guix T, Prat G, Jane F, Casas M. Is experimental catalepsy properly measured? Pharmac Biochem Behav 1990;35:753-7.     
14.       Samberg PR. Haloperidol induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 1980;284:472-3.     
15.       Ossowska K. Neuronal basis of neuroleptic-induced extrapyramidal side effects. Polish J Pharmacol 2002;54:299-312.     
16.       Polydoro M, Schroder N, Lima MN, Caldana F, Laranja DC, Bromberg E, et al . Haloperidol and clozapine induced oxidative stress in the rat brain. Pharmacol Biochem Behav 2004;78:751-66.    [PUBMED]  [FULLTEXT]
17.       Marti-Masso JF, Poza JJ, Lopez de Munain A. Drugs inducing or aggravating parkinsonism: A review. Therapie 1996;51:568-77.    [PUBMED] 

1.         Kibbe AH, editor. Handbook of pharmaceutical excipients. 3 rd ed. London (UK); The Pharmaceutical Press: 2000.     
2.         Tripathy S, Promod K, Banthia AK. Novel delivery system for aceclofenac. Scientific abstract, 56 th Indian Pharmaceutical Congress: 2004. p. A71.     
3.         Poddar SS, Saini CR, Paresh A, Singh R. The microencapsulation of ibuprofen by gelatin-carrageenan complex coacervation. Scientific abstract, 56 th Indian Pharmaceutical Congress: 2004. p. AP111.     
4.         Bharadia PD, Patel MM, Patel GC, Patel GN. A preliminary investigation on sesbania gum as a pharmaceutical excipient. Int J Pharma Excip 2004;3:99-102.     
5.         Srinivas K, Prakash K, Kiran HR, Prasad PM, Rao ME. Study of Ocimum basilicum and Plantago ovata as disintegrants in the formulation of dispersible tables. Indian J Pharm Sci 2003;65:180.     
6.         Gilbert VL. Tagatose, the new GRAS sweetener and health product. J Med Food 2002;5:23-36.     
7.         Khanna M, Nandi RC, Singh S, Jain GK. Standardization of pure isapgol (Plantago ovata) mucilage for pharmaceutical use. Indian J Pharm Sci 1988;50:238-40.     
8.         Gowthamarajan K, Kulkarni GT, Muthukumar A, Mahadevan N, Samantha MK, Suresh B. Evaluation of fenugreek mucilage as gelling agent. Int J Pharma Excip 2002;3:16-9.     
9.         Banker GS, Anderson NR. Tablets. In: Lachman L, Lieberman HA, Kanig JL, editors. The theory and practice of industrial pharmacy. 3 rd ed. Mumbai; Varghese Publishing House: 1987. p. 336.     
10.       Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 24 th ed. Pune; Nirali Prakashan: 2003. p. 109.     
11.       Indian Pharmacopoeia. 4 th ed. Ministry of health and family welfare, Govt. of India, New Delhi; Controller of publications: 1996. p. A-54.     
12.       British Pharmacopoeia. volume 2, 2000. p. A-207, 210.     
13.       Indian Pharmacopoeia. 2 nd ed. Ministry of health and family welfare, Govt. of India, New Delhi; Controller of publications: 1966. p. 740.     
14.       Indian Pharmacopoeia. 4 th ed. Ministry of health and family welfare, Govt. of India, New Delhi; Controller of publications: 1996. p. A-80.     
15.       Indian Pharmacopoeia. 4 th ed. Ministry of health and family welfare, Govt. of India, New Delhi; Controller of publications: 1996. p. A-82.     
16.       USP 24 and NF 19. Rockville, MD; US Pharmacopoeial Convention, Inc: 2000. p. 1941.     
Aguiyi, J. C.; Obi, C. I.; Gang, S. S and Igweh, A. C. (2000), Hypoglycaemic activity of Ocimum gratissimum in rats. Fitoterapia, 71, 444-446.        [ Links ]
Atal, C. K.; Sharma, M. L.; Kaul, A. and Khajuria, A. (1986), Immunomodulating agents of plant origin, I: Preliminary screening. Journal of Ethnopharmacology, 18, 133-141.        [ Links ]
Ayisi, N. K. and Nyadedzor, C. (2003), Comparative in vitro effects of AZT and extracts of Ocimum gratissimum, Ficus polita, Clausena anisata, Alchornea cordifolia, and Elaeophorbia drupifera against HIV-1 and HIV-2 infections. Antiviral Research, 1766, 1-9.        [ Links ]
Cimanga, K.; Kambu, K.; Tona, L.; Apers, S.; Bruyne, T.; Hermans N.; Totté, J.; Pieters, L. and Vlietinck, A. J. (2002), Correlation between chemical composition and antibacterial activity of essential oils of some aromatic medicinal plants growing in the Democratic Republic of Congo. Journal of Ethnopharmacology, 79, 213-220.        [ Links ]
Corrêa, M. P. (1926), Dicionário das Plantas Úteis do Brasil e das Exóticas Cultivadas. Rio de Janeiro: Imprensa Nacional.        [ Links ]
Dubey N. K.; Tiwari, T. N.; Mandin, D.; Andriamboavonjy, H. and Chaumont, J. P. (2000), Antifungal properties of Ocimum gratissimum essential oil (ethyl cinnamate chemtype). Fitoterapia, 71, 567-569.        [ Links ]
Homans, A. L. and Fuchs, A. (1970), Direct bioautography on thin-layer chromatograms as a method for detecting fungitoxic substances. J. Chromatogr., 51, 327-329.        [ Links ]
Janssen, A. M.; Scheffer, J. J. C.; Ntezurubanza, L. and Svendsen, A. B. (1989), Antimicrobial activities of some Ocimum species grown in Rwanda. Journal of Ethnopharmacology, 26, 57-63.        [ Links ]
Kéita, S. M.; Vincent, C.; Schmit, J. P.; Arnason, J. T. and Bélanger, A. (2001), Efficacy of essential oil of Ocimum basilicum L. and O. gratissimum L. applied as an insecticidal fumigant and powder to control Callosobruchus maculatus (Fab.) [Coleoptera: Bruchidae]. Stored Products Research, 37, 339-349.        [ Links ]
Lorenzi, H. and Matos, F. J. A. (2002), Plantas Medicinais no Brasil Nativas e Exóticas. Nova Odessa: Instituto Plantarum de Estudos da Flora.        [ Links ]
Madeira, S. V. F.; Matos, F. J. A.; Leal-Cardoso, J. H. and Criddle, D. N. (2002). Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig. Journal of Ethnopharmacology, 81, 1-4.        [ Links ]
Nakamura, C. V.; Ueda-Nakamura, T.; Bando, E.; Melo, A. F. N.; Cortez, D. A. G. and Dias Filho, B. P. (1999), Antibacterial Activity of Ocimum gratissimum L. Essential Oil. Mem. Inst. Oswaldo Cruz, 94, 675-678.        [ Links ]
Ngassoum, M. B.; Essia-Ngang, J. J.; Tatsadjieu, L. N.; Jirovetz, L.; Buchbauer, G. and Adjoudji, O. (2003), Antimicrobial study of essential oils of Ocimum gratissimum leaves and Zanthoxylum xanthoxyloides fruits from Cameroon. Fitoterapia, 74, 284-287.        [ Links ]
Offiah, V. N. and Chikwendu, U. A. (1999), Antidiarrhoeal effects of Ocimum gratissimum leaf extract in experimental animals. Journal of Ethnopharmacology, 68, 327-330.        [ Links ]
Onajobi, F. D. (1986), Smooth muscle contracting lipid-soluble principles in chromatographic fractions of Ocimum gratissimum. Journal of Ethnopharmacology, 18, 3-11.        [ Links ]
Pessoa, L. M.; Morais, S. M.; Bevilaqua, C. M. L. and Luciano, J. H. S. (2002), Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Veterinary Parasitology, 109, 59-63.        [ Links ]
Saito, T.; Hayamizu, K.; Yanagisawa, M.; Yamamoto, O.; Wasada, N.; Kinugasa, S.; Tanabe, K. and Tamura, T. (2004), Integrated Spectral Data Base System for Organic Compounds. Available at: http://www.aist.go.jp/RIODB/SDBS/. Accessed in: 30 Sept., 2004.        [ Links ]
Silva, M. G. V.; Craveiro, A. A.; Matos, F. J. A.; Machado, M. I. L. and Alencar, J. W. (1999), Chemical variation during daytime of constituents of the essential oil of Ocimum gratissimum leaves. Fitoterapia, 70, 32-34.        [ Links ]
Still, W. C.; Kahn, M. and Mitra, A. (1978), Rapid chromatographic technique for preparative separations with moderate resolution. J. Org. Chem., 43, 2923-2925.        [ Links ]
Vieira, R. F.; Grayer, R. J.; Paton, A. and Simon, J. E. (2001), Genetic diversity of Ocimum gratissimum L. based on volatile oil constituents, flavonoids and RAPD markers. Biochemical Systematics and Ecology, 29, 287-304.        [ Links ]

1.  Akinyemi, K.O., Mendie, U.E., Smith, S. T., Oyefolu, A.O. and Coker, A.  O. (2004)
Screening of some medicinal plants for anti salmonella activity.  J. Herb Pharmocother
5(1):45-60.
2.  Aureli, P., Constantini, A., and Zolea, S. (1992).  Antimicrobial  activity  of some plant
essential oils  against  Listeria  monocytogenes. J. Food Prot., 55: 344-348.
3.  Chatterje, A., Sukul, NC., Laskel, S. and Ghoshmajumadar, S. (1982). Nematicides
principal from two species of Lamiaceae. J. Nematol. 14:118-120
4.  Begum, J., Yusuf, M., Chowdhury, U., and Wahab, MA (1993). Studies on essential oils
for their antibacterial and antifungal properties.  Part 1. Preliminary screening of 35
essential oils. J. Sci, Ind. Res., 28: 25-34.
5.  Chavan, S. R. and Nikam, ST. (1982). Mosquito larvicidal  activity of Ocimum basilicum
Linn.  India J. Med. Res. 75:220 – 222.
6.  Chogo, JB., and Crank, G. (1981). Chemical composition and biological activity of the
Tanzania plant Ocimum suave, J. Nat. Prot., 44 (3): 308-311.
7.  Correa, MP(1932). Dicionario das plantas uteis do Brasil. IBDF, Rio de Janeiro.
8.  Craveiro, AA., Fernandes, AG., Andrade, CHS., Matos, FJA., and Alencar, WJ (1981).
Oleos essenciais de plantas do Nordeste, Imprensa Universitaria. Universidade Federal do
Ceard, Fortaleza.
9.  Curtis, GD (2000). Detection by Classical cultural Techniques. Encyclopedia  of Food
Microbiology, Bacteriology Department, John Ratclife Hospital, Oxford, UK. PP. 119-
1207.
10. Desphande, RS., and Tipnis, HP (1977).  Insecticidal activity of Ocimum basilicum L.
Pesticides., 11:11-12
11. Dimitrijevic, M and Teodorovic,  V. (1998). Importance of food animal origin in genesis
of alimentary Listeriosis. Veterinarski Glasniki., 52 (1-2): 79-85.
12. El-said, F., Sofowora, EA., Malcolm, SA., and Hofer, A (1969). An Investigation into
the efficacy of Ocimum  gratissimum as used in Nigeria native medicine. Planta Medica.,
97: 195-200
13. Ilori, M., Sheteolu, AO.  Omonibgehin, EA., and Adeneye, AA (1996). Antibacterial
activity of Ocimum gratissimum  (Lamiaceae) J. Diarrhoeal Dis Res., 14:283-285.
14. Iwalokun, RA., Gbenle, GO., Adewole, TA.,  Smith, SI.,  Akinsinde,  KA., and
Omonighehin, EO (2003). Effects of  Ocimum gratissimum  L. essential oil at subinhibitory  concentration on virulent and multi drug resistant Shigella strains from Lagos,
Nigeria, APMIS., III (4): 477-82
15.  Janine de Aquino Lemos, Xisto Sena Passos, Orionaida de Fatima Lisboa Fernande, Jose
Realino de Paula, Pedro Henrique Ferri,  Lucia  Kioko Hasimoto de Souza, Aline de
Aquino Lemos Maria de Rosario Rodrigues Silva (2005). Antifungal activity fromOcimum gratissimum  L. towards  Cryptococcus neoformans. Mem.  Inst. Oswaldo Cruz
100(1): 55 – 58.
16. Lopez, P. Sanchez, K. Batlle, R and Nerin, C (2005) Solid and vapor phase anti-microbial
activities of six essential oils susceptibility of selected food borne bacterial and fungal
strains. J. Agric Food Chem. 53 (17): 6939-6946. 
17. Maijala, R., Lyykikainen, O., Johansson, T., Autio, T. Aaito, T., Haavisto, L and
Honkane – Buziski, T. (2001). Exposure of Listeria monocytogenes  within an epidemic
caused by butter in Finland. International. J. of  food Microbiology., 70 (1-2): 97-109.  
18 Marsden, JL. (1994). Industry perspective on Listeria  monocytogenes in food: raw meat
and poultry. Dairy, Food and Environmental Sanitation 14 (2): 83-86.
19. Martion, SE and Fisher, CW (2000).  Listeria monocytogenes. In R. K.  Robinson, C. A.
Batt, and P.D. Petal (Eds). Encyclopaedia  of food Microbiology  Academic Press, San
Diego, CA. Pp. 1228-1238
20. Mshana, NR., Abbiw, DK,  Addae – Mensah, I., Adjanohoun, E., Ahji, MRA., EnowOrock, EG., Gbile, ZO, Noamesi, BK., Odei MA., Adenlami, H., Oteng-Yeboah, AA., I.
Sarppony, K.,  Sofowora, A.,  and Tackie, AN (2000). Traditional medicine and
pharmacopoeia  contribution to the revision of Ethnobotanical and floristic  studies in
Ghana, Scientific, Technical and Research Commission of the Organization of African
Unity.
21. Nakamura, CV., Nakamura, TV., Bando, E., Melo AFN., Cortez, DAG. And Dias Filho,
BP (1999). Antibacterial activity of  Ocimum gratissimum  L. essential oil.  Mem. Inst.
Oswaldo Cruz., 94:675-678
22. Ntezurubanza, L. I Scheffer, JJC.,  Looman, A. and Baerhiem Svends  (1984).
Composition  of essential oil of Ocimum kilimandscharicum grown in Rwanda.  Plant.
Medica., 385-388.
23.  Nwosu, MO., and Okafor, JI, (1995) Preliminary studies of the  antifungal activities of
some medicinal plants against Basidiobolus and some other pathogenic fungi. Mycoses.,
38: 191-195
24. Onajobi. FD (1986).  Smooth muscle contracting lipid soluble principles in
chromatographic fractions of Ocimum  gratissimum. J.Ethnopharmacol., 18:3-11.
25.  Pessoa, LM. Morais, SM. Bevilaque, CML. and  Luciano, JHS.,  (2002). Antihelmintic
activity of essential oil of Ocimum gratissimum  Linn, and eugenol against  Heamonchus
contortus Vet. Parasitol., 109:  59-63.
26. Reuveni, RA., Fleisher and Putievsky, E. (1984). Fungistic activity of essential oils from
Ocimum basilicum chemotypes  Phytopath.,  110:20-22.
27. Roitman, C.M Roitman, I., and Azevedo, HP (1972) Growth of an insect Trypanosomatid
at 37
0
C in a defined medium. J. Protozool. 19:346-349.  
  • Bailey, L.H. 1924. Manual of cultivated plants. MacMillan Co. New York.
  • Charles, D.J. and J.E. Simon. 1990. Comparison of extraction methods for the rapid determination of essential oil content and composition of basil (Ocimumspp.) J. Amer. Soc. Hort. Sci. 115:458-462.
  • Charles, D.J., J.E. Simon, and K.V. Wood. 1990. Essential oil constituents of Ocimum micranthum Willd. J. Agric. Food Chem. 38:120-122.
  • Chatterje, A., N.C. Sukul, S. Laskal, and S. Ghoshmajumdar. 1982. Nematicidal principles from two species of Lamiaceae. J. Nematol. 14:118-120.
  • Chavan, S.R and S.T Nikam. 1982. Mosquito larvicidal activity of Ocimum basilicum Linn. Indian J. Med Res. 75:220-222.
  • Chogo, J. B. and G. Crank. 1981. Chemical composition and biological activity of the Tanzanian plant Ocimum suave. J. Nat. Prod 44(3):308-311.
  • Darrah, H.H. 1980. The cultivated basils. Buckeye Printing Company, Independence, MO.
  • Deshpande, R.S., and H.P. Tipnis. 1977. Insecticidal activity of Ocimum basilicum L. Pesticides 11:1 1-12.
  • Fleischer, A. 1981. Essential oils from two varieties of Ocimum basilicum L. grown in Israel. J. Sci. Food Agric. 32:1119-1122.
  • Guenther, E. 1949. The essential oils. VIII. Robert E. Krieger Publ. Co. Malabar, Florida. p. 399-433.
  • Heath, H.B. 1981. Source book of flavors. AVI. Westport, CT. p. 222-223.
  • Lawrence, B.M., J.W. Hogg, S.J. Terhune and N. Pichitakul. 1972. Essential oils and their constituents. IX. The oils of Ocimum sanctum and Ocimum basilicum from Thailand. Flavor Ind Jan. 47-49.
  • Nishida, R., W.S. Bowers, and P.H. Evans. 1984. Synthesis of highly active juvenile hormone analogs, juvocimene I and II, from the oil of sweet basilOcimum basilicum L. J. Chem. EcoL 10:1435-1450.
  • Ntezurubanza, L, J.J.C. Scheffer, A. Looman, and A. Baerhiem Svendsen. 1984. Composition of essential oil of Ocimum kilimandscharicum grown in Rwanda. Planta Medica 385-388.
  • Reuveni, R, A. Fleisher, and E. Putievsky 1984. Fungistatic activity of essential oils from Ocimum basilicum chemotypes. Phytopath. Z. 110:20-22.
  • Simon, J.E. and D. Reiss-Bubenheim. 1987. Field performance of American basil varieties. Herb, Spice and Medicinal Plant Dig. 6 (1):1-4. (Mass. Coop. Ext. Serv, Amherst).
  • Simon, J.E., L.E. Craker, and A. Chadwick 1984. Herbs: an indexed bibliography, 1971-1980. The scientific literature on selected herbs, and aromatic and medicinal plants of the temperate zone. Archon Books, Hamden, CT.
  • Sobti, S.N., P. Pushpangadan and C.K. Atal. 1982. Clocimum: A new hybrid strain of Ocimum gratissimum as a potential source of clove type oil, rich in eugenol. In: Atal, C.K. and B.M. Kapur (eds.). Cultivation and utilization of aromatic plants. Reg. Res. Lab., Jammu-Tawi, India p. 473-480.
  • Staff of L.H. Bailey Hortorium. 1976. Hortus III. MacMillan, New York.
[1] Marotti M, Piccaglia R, Giovanelli E. 1996.
Differences in essential oil composition of basil 
(Ocimum basilicum L.) Italian cultivars related to
morphological characteristics. J.Agric.Food Chem.
44:3926-3929.
[2] Morris JA, Khettry A, Seitz EWM. 1979.
Antimicrobial activity of aroma chemicals and
essential oils. J.Am.Oil Chem. Soc. 56:595-603.
[3] Lee KD, Yang MS. 2005. Changes in mineral and
terpene concentration following calcium fertilization
of  Chrysanthemum boreale  M. Research Journal of
Agriculture and Biological Sci. 1: 222-226.
[4] Merk L, Kloos M, Schonwitz R, Ziegler H. 1988.
Influence of various factors on quantitiative
composition of leaf monoterpenes of Picea abies (L.)
Karst. Trees.2: 45-51.
[5] Muzika RM., Pregitzer KS, Hanover JW. 1989.
Changes in terpene production following nitrogen
fertilization of grand fir (Abies grandis  (Dougl.)
Lindl.) seedlings. Oecologia. 80: 485-489.
[6] Ram M, Ram D, Singh S. 1995. Irrigation and nitrogen
requirements of Bergamot mint on a sandy loam soil
under sub-tropical conditions. Agr. Water Manage.
27:45-54.
[7] Ram M, Kumar S. 1997.  Yield improvement in the
regenerated and transplanted mint  Mentha arvensis
by recycling the organic wastes and manures. Biores.
Technol. 59: 141-149.
[8] Ram M, Ram D, Roy SK. 2003. Influence of an
organic mulching on fertilizer nitrogen use efficiency
and herb and essential oil yields in geranium
(Pelargonium graveolens). Biores. Technol. 87:273-
278.
[9] Kandeel AM, Naglaa SAT, Sadek AA. 2004. Effect of
biofertilizers on the growth, volatile oil yield and
chemical composition of Ocimum basilicum L. plant.
Ann.Agr.Sci.Cairo. 1:351-371.
[10] Adler PR, Simon JE, Wilcox GE. 1989. Nitrogen
from alters basil growth and essential oil content and
composition. Hort.Sci. 24:789-790.
[11] Meneghini A, Pocceschi N, Venanzi G, Tomaselli
PB. 1998. Effect of nitrogen fertilization on
photosynthetic rate, nitrogenous metabolites and  β-
asarone accumulation in triploid Acorus calamus L.
leaves. Flavour Frag. J. 13:319-323.
[12] Rao BRR. 2001. Biomass and essential oil yields of
rainfed palmarosa (Cymbopogon martinii (Roxb)
wats var.motia Burk) supplied with different levels of
organic manure and fertilizer nitrogen in semi-arid
tropical climate. Ind. Crop Prod. 14:171-178.
 [13] Sangwan NS, Farooqi AHA, Shabih F, Sangwan RS.
2001. Regulation of essential oil production in plants.
Plant Growth Regul. 34:3-21.
[14] Sahin F, Güllüce M, Dafera D, Sökmen A,  Sökmen
M, Polissiou M, Agar G,  Ozer H. 2004. Biological
activities of the essential oils and methanol extract of
Origanum vulgare ssp.  vulgare in the Eastern
Anatolia region of Turkey. Food Control. 15:549-
557.
[15] Sifola MI, Barbieri G. 2006. Growth, yield and
essential oil content of three cultivars of basil grown
under different levels of nitrogen in the field. Scientia
Horticulturae. 108:408-413. 
[16] Youssef AA, Talaat IM, Omer E.A. 1998.
Physiological response of basil Green Ruffles
(Ocimum basilicum L.) to nitrogen fertilization in
different soil types. Egyptian Journal of Horticulture.
25: 253-269. 
[17] Golcz, A, Politycka B, Seidler-Lozykowska K.2006.
The effect of nitrogen fertilization and stage of plant
development on the mass and quality of sweet basil
leaves (Ocimum basilicum L.). Herba Polonica. 
52: 22-30. 
[18] Kothari SK, Bhattacharya AK, Ramesh S. 2004.
Essential oil yield and quality of methyl eugenol rich
Ocimum tenuiflorum L.f.(syn.O.sanctum L.) grown in
south India as influenced by method of harvest. J.
Chromatography A. 1054:67-72.
[19] Telci I. 2005. Determination of suitable harvesting
height in basil (Ocimum basilicum L.) genotypes.
Gazi Osmanpaşa University, Journal of Agricultural
Faculty. 22:77-83.
[20] Ozcan M, Chalchat JC. 2002. Essential oil
composition of  Ocimum basilicum L. and  Ocimum
minimum L. in Turkey. Czech J. Food Sci. 20:223-
228.
[21] Telci I, Bayram E, Yılmaz G, Avcı B. 2006.
Variability in essential oil composition of Turkish
basils (Ocimum basilicum L.). Biochemical
Systematics and Ecology. 34:489-497.
[22] Zheljazkov VD, Callahan A, Cantrell CL. 2008. Yield
and oil composition of 38 basil (Ocimum basilicum
L.) accessions grown in  Mississippi. J. Agr.Food
Chem.56:241-245. 
[23] Arabaci O, Bayram E. 2004. The effect of nitrogen
fertilization and different plant densities on some
agronomic and technologic characteristic of Ocimum
basilicum L. (Basil). Journal of Agronomy. 3:255-
262.
[24] Ozgüven M, Kirpik M, Sekeroğlu N. 2001.
Determination of the optimal sowing time and
nitrogen fertilization for lavender (Lavandula
angustifolia Mill.)in the Çukurova conditions. In:
Proceedings of the Workshop on Agricultural and
Quality Aspects of Medicinal and Aromatic Plants, ,
May 29-June 1,2001, pp217-223. Adana, Turkey.
[25] Ashraf M, Qasim A, Zafar I. 2006. Effect of nitrogen
application rate on the content and composition of
oil, esential oil and minerals in black cumin (Nigella
sativa L.) seeds. J.Sci.Food Agric. 86:871-876.
[26] Sekeroğlu N, Ozgüven M.2006. Effects of different
nitrogen doses and plant densities on yield and
quality of  Oenothera biennis L. grown in irrigated
lowland and un-irrigated dryland conditions.
Turk.J.Agric.Forest. 30:125-135.
[27] Ozgüven M, Sener B, Orhan I, Sekeroğlu N, Kirpik
M., Kartal M, Pesin I,  Kaya Z. 2008. Effects of
vsrying nitrogen doses on yield, yield components
and artemisinin content of  Artemisia annua L.
Industrial Crops and Products. 27: 60-64
1.  Cardoso SRS, Eloy NB, Provan J, Cardoso MA, Ferreira PCG (2000).  Genetic differentiation of  Euterpe
edulis Mart populations estimated by AFLP analysis. Mol. Ecol. 9: 1753-1760.
2.  Chen X, Yang J (2004). Species – diversified plant cover enhances orchard ecosystem resistance to climatic
stress and soil erosion in subtropical hillside. J. Zhejiang. Uni. Sci. 5(10): 1191-1198.
3.  Doyle and Doyle (1987). A rapid DNA isolation procedure for small quantities of fresh leaf tissues. Phytoch.
Bull. 19: 11-15.
4.  Ipek M, Madison L (2001). Genetic Diversity in Garlic (Allium sativum L.) as assessed by  AFLPs and
Isozymes. American Society for Horticultural Science 98th Annual Conference & Exhibition — 22 - 25.
5.  Lei Y, Gao H, Tsering T, Shi S, Zhong Y (2006). Determination of genetic variation in Rhodiola crenulata
from the Hengduan Mountain Region, China using inter-simple sequence repeats. Genet. Mol. Biol. Sao Paulo
(29): 2.
6.  M’Ribu, H.K., and Hilu, K.W. 1994. Detection of interspecific and intraspecific variation in Panicum millets
through random amplified polymorhic DNA. Theor. Appl. Genet. 88: 412–416.
7.  Mabberley DJ (1997). The plant Book: A portable Dictionary of the Higher plants (second edition). Useful,
dictionary of genera and families of angiosperms. In: FREMONTIA. J. California Native Plant Soc. 30(2): 1-
36, 2002.
8.  Matasyoh LG, Matasyoh JC, Wachira FN, Kinyua MG, Muigai Thairu AW, Mukiama TK (2007). Chemical
composition and antimicrobial activity of the essential oil of Ocimum gratissimum L. growing in  Eastern
Kenya. Afr. J. Biotechnol. 6(6): 760-765.
9.  Muluvi GM, Sprent JI, Soranzo N, Provan J, Odee D, Folkard G, McNicol JW, Provan J, Powell W (1999).
Amplified fragment length polymorphism (AFLP) analysis of genetic variation in Moringa. Mol. Ecol. 8: 463-
470.
10.  Nakamura CV, Nakamura TV, Bando E, Melo AFN, Cortez DAG, Dias Filho BP (1999). Antibacterial activity
of Ocimum gratissimum L. essential oil. Mem. Inst. Oswaldo Cruz. (94): 675-678.
11.  Nan P, Shi SH, Peng ST ,Tian Cj ,Zhong Y (2003). Genetic diversity in Primula obconica (Primulaceae) from
central and south-west China as revealed by ISSR markers. Ann. Bot. 91: 329-333.
12.  Nybom H (1990). Application of DNA fingerprinting in plant breeding. Proc. Intern. DNA Fingerprinting
Symposium. Bern. pp. 32-45.
13.  Paran, I., Kesseli, R., and Michelmore, R. 1991. Identification of RFLP and RAPD markers linked to downey
mildew resistance gene in lettuce using near-isogenic lines. Genome, 34: 1021–1027.
14.  Priya joy and M. Maridass. Ethnobotanical Leaflets 12: 476-480. 2008.
15.  Salimah, S.S., De Oliveira, A.C., Godwin I. D (1995). Assessment of genomic origin and genetic diversity in
the genus Eleusine with DNA markers. Genomic. 38: 757–763.
16.  Sang-Bok Lee, and Soren K. Rasmussen, 2000. Molecular markers in some medicinal plants of the Apiaceae
family. Euphytica, 114: 87–91.17.  The Wealth of India, (1992). A Dictionary of Indian Raw materials and Industrial products, III Publications
and Information Directorate, New Delhi, p. 582-590.
18.  Valle, P.R., Souza, M.B., Pires, E.M., Silva, E.F., and Gomes, M.A. 2000. Arbitrarily primed PCR
fingerprinting of RNA and DNA in Entamoeba histolytica. Rev. Inst. Med. Trop. Sao Paulo, 42(5): 249–253.
19.  Williams JGK, Kubelik AR, Livak KJ, Rafalski JA and Tingey SV (1990) DNA polymorphisms amplified by
arbitrary primers are useful as genetic markers. Nucleic Acids Research 18:6531-6535.
20.  Wren RW (1968). Potter’s New Cyclopedia for Botanical Drugs and Preparations by Wren RC. Re-edit by
Wren RW. Potter and Clarke, Ltd. Health Science Press, Rustington, Sussex.
1. Mitchell SW: Injuries of nerves and their consequences. Philadephia; J. B.
Lippincott 1872.
2. Woolf CJ, Mannion RJ: Neuropathic pain, aetiology, symptoms,
mechanisms and management. Lancet 1999, 353:1959-1964.
3. Werhagen L, Budh CN, Hultling C, Molander C: Neuropathic pain after
traumatic spinal cord injury relations to gender, spinal level,
completeness, and age at the time of injury. Spinal Cord 2004,
42:665-673.
4. Alston RP, Pechon P: Dysesthesia associated with sternotomy for heart
surgery. Br J Anaesth 2005, 95:153-158.
5. Bromberg MB: Peripheral neurotoxic disorders. Clin Neurobehav Toxicol
2000, 18:681-689.
6. Pal PK: Clinical and electrophysiological studies in vincristine induced
neuropathy. Electromyogr Clin Neurophysiol 1999, 39:323-330.
7. Kalita J, Vajpayee A, Misra UK: Comparison of prednisolone with piroxicam
in complex regional pain syndrome following stroke: a randomized
controlled trial. QJM 2006, 99(2):89-95.
8. Yanpallewar SU, Sunita R, Mohan K, Acharya SB: Evaluation of antioxidant
and neuroprotective effect of Ocimum sanctum on transient cerebral
ischemia and long-term cerebral hypoperfusion. Pharmacol Biochem
Behav 2004, 79:155-164.
9. Jaggi RK, Madaan R, Singh B: Anticonvulsant potential of holy basil,
Ocimum sanctum Linn., and its cultures. Indian J Exp Biol 2003,
41:1329-1333.
10. de Almeida I, Alviano DS, Vieira DP, Alves PB, Blank AF, Lopes AH,
Alviano CS, Rosa MS: Antigiardial activity of Ocimum basilicum essential
oil. Parasitol Res 2007, 101:443-452.
11. Bhattacharyya D, Sur TK, Jana U, Debnath PK: Controlled programmed trial
of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll
J 2008, 10(3):176-179.
12. Balanehru S, Nagarajan B: Protective effect of oleanolic acid and ursolic
acid against lipid peroxidation. Biochem Int 1991, 24:981-990.
13. Anandjiwala S, Kalola J, Rajani M: Quantification of eugenol, luteolin,
ursolic acid, and oleanolic acid in black (Krishna Tulasi) and green (Sri
Tulasi) varieties of Ocimum sanctum Linn. using high-performance thinlayer chromatography. J AOAC Int 2006, 89:1467-1474.
14. Muthuraman A, Diwan V, Jaggi AS, Singh N, Singh D: Ameliorative effects
of Ocimum sanctum in sciatic nerve transection-induced neuropathy in
rats. J Ethnopharmacol 2008, 120(1):56-62.
15. Rhiouani H, Settaf A, Lyoussi B, Cherrah Y, Lacaille-Dubois MA, Hassar M:
Effects of saponins from Herniaria glabra on blood pressure and renal
function in spontaneously hypertensive rats. Therapie 1999, 54(6):735-739.
16. Shibata S: Chemistry and Cancer Preventing Activities of Ginseng
Saponins and Some Related Triterpenoid Compounds. J Korean Med Sci
2001, 16:28-37.
17. Pal D, Sahoo M, Mishra AK: Analgesic and anticonvulsant effects of
Saponin isolated from the stems of Opunntia vulgaris mill. in mice. Eur
Bull Drug Res 2005, 13:91-97.
18. Chen ZH, Li J, Liu J, Zhao Y, Zhang P, Zhang MX, Zhang L: Saponins
isolated from the root of Panax notoginseng showed significant antidiabetic effects in KK-Ay mice. Am J Chin Med 2008, 36(5):939-951.
19. Wang LC, Wang B, Ng SY, Lee TF: Effects of ginseng saponins on betaamyloid-induced amnesia in rats. J Ethnopharmacol 2006, 103(1):103-108.
20. Al-Habori M, Raman A: Antidiabetic and hypocholesterolaemic effects of
fenugreek. Phytother Res 1998, 12:233-242.
21. Kim JH, Kim S, Yoon IS, Lee JH, Jang BJ, Jeong SM, Lee JH, Lee BH, Han JS,
Oh S, Kim HC, Park TK, Rhim H, Nah SY: Protective effects of ginseng
saponins on 3-nitropropionic acid-induced striatal degeneration in rats.
Neuropharmacology 2005, 48(5):743-756.
22. Moharram FA, El-Shenawy SM: Antinociceptive and anti-inflammatory
steroidal saponins from Dracaena ombet. Planta Med 2007,
73(10):1101-1106.
23. Wang J, Zhou H, Jiang Z, Wong Y, Liu L: In Vivo Anti-inflammatory and
Analgesic Activities of a Purified Saponin Fraction Derived from the Root
of Ilex pubescens. Biol Pharm Bull 2008, 31(4):643-650.
24. Yin X, Zhang Y, Wu H, Zhu X, Zheng X, Jiang S, Zhuo H, Shen J, Li L, Qiu J:
Protective effects of Astragalus saponin I on early stage of diabetic
nephropathy in rats. J Pharmacol Sci 2004, 95(2):256-266.
25. Liu J, Li Y, Yuan X, Yang Z, Lin Z: Sodium beta-aescin may be an effective
therapeutic agent for Bell’s palsy. Med Hypotheses 2008, 71(5):762-764.
26. Ebata N, Nakajima K, Hayashi K, Okada M: Maruno Saponins from the root
of Bupleurum falcatum. Phytochemistry 1996, 41(3):895-901.
27. Sadraei H, Asghari G, Hekmatti AA: Antispasmodic effect of three fractions
of hydroalcoholic extract of Pycnocycla spinosa. J Ethnopharmacol 2003,
86(2-3):187-190.
28. Siau C, Bennett GJ: Dysregulation of neuronal calcium homeostasis in
chemotherapy-evoked painful peripheral neuropathy. Anesth Analg 2006,
102:1485-1490.
29. Decosterd I, Woolf CJ: Spared nerve injury: an animal model of persistent
peripheral neuropathic pain. Pain 2000, 87:149-158.
30. Jain V, Jaggi AS, Singh N: Ameliorative potential of rosiglitazone in tibial
and sural nerve transection-induced painful neuropathy in rats.
Pharmacol Res 2009, 59(6):385-392.
31. Erichsen HK, Blackburn-Munro G: Pharmacological characterization of the
spared nerve injury model of neuropathic pain. Pain 2002, 98:151-161.
32. Necker R, Hellon RF: Noxious thermal input from the rat tail: modulation
by descending inhibitory influences. Pain 1978, 4:231-242.
33. Muthuraman A, Jaggi AS, Singh N, Singh D: Ameliorative effects of
amiloride and pralidoxime in chronic constriction injury and vincristineinduced painful neuropathy in rats. Eur J Pharmacol 2008, 587:104-111.
34. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with
folin phenol reagent. J Biol Chem 1951, 193:265-275.
35. Okhawa H, Ohishi N, Yagi K: Assay for lipid peroxidation in animal tissue
by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
36. Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quinn MT, Brecher P, Cohen RA:
Superoxide anion from the adventitia of the rat thoracic aorta
inactivates nitric oxide. Circ Res 1998, 82:810-818.
37. Severinghaus JW, Ferrebee JW: Calcium determination by flame
photometry; methods for serum, urine, and other fluids. J Biol Chem
1950, 187:621-630.
38. Lu J, Zheng YL, Wu DM, Luo L, Sun DX, Shan Q: Ursolic acid ameliorates
cognition deficits and attenuates oxidative damage in the brain of
senescent mice induced by D-galactose. Biochem Pharmacol 2007,
74(7):1078-1090.
39. Somova LO, Nadar A, Rammanan P, Shode FO: Cardiovascular,
antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids
in experimental hypertension. Phytomedicine 2003, 10(2-3):115-121.
40. Senthil S, Chandramohan G, Pugalendi KV: Isomers (oleanolic and ursolic
acids) differ in their protective effect against isoproterenol-induced
myocardial ischemia in rats. Int J Cardiol 2007, 119(1):131-133.
41. Manu KA, Kuttan G: Ursolic acid induces apoptosis by activating p53 and
caspase-3 gene expressions and suppressing NF-kappaB mediated
activation of bcl-2 in B16F-10 melanoma cells. Int Immunopharmacol
2008, 8(7):974-981.
42. Kamei J, Tamura N, Saitoh A: Possible involvement of the spinal nitric
oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
Pain 2005, 117:112-120.
43. George S, Chaturvedi P: Protective role of Ocimum sanctum plant extract
in alcohol-induced oxidative stress in albino rats. Br J Biomed Sci 2008,
65(2):80-85.
44. Doan TN, Gentry DL, Tylor AA, Elliott SJ: Hydrogen peroxide activates
agonist-sensitive Ca
2+
influx pathways in canine venous endothelial
cells. Biochem J 1994, 297:209-215.
45. Kawakami M, Okabe E: Superoxide Anion Radical-Triggered Ca
2+
Release
from Cardiac Sarcoplasmic Reticulum through Ryanodine Receptor Ca
2+
Channel. Mol Pharmacol 1998, 53(3):497-503.
46. Feresin GE, Tapia A, Gutierrez RA, Delporte C, Backhouse Erazo N, SchmedaHirschmann G: Free radical scavengers, anti-inflammatory and analgesic
activity of Acaena magellanica. J Pharm Pharmacol 2002, 54(6):835-844.
47. Tao J, Wang H, Zhou H, Li S: The saponin monomer of dwarf lilyturf
tuber, DT-13, reduces L-type calcium currents during hypoxia in adult
rat ventricular myocytes. Life Sci 2005, 77(24):3021-3030.
48. Li W, Li W, Yin Y, Gong H, Wu G, Zhu F: Protective effects of AST and ASI
on memory impairment and its mechanism in senescent rats treated by
GC. Zhongguo Zhong Yao Za Zhi 2009, 34(2):199-203.
49. Li Y, Chen X, Liu H, Luo F, Li G: Effects of ginseng total saponins with
berberine on plasma brain natriuretic peptide and Ca
2+
concentration in
experimental rats with chronic congestive heart failure. Zhongguo Zhong
Yao Za Zhi 2009, 34(3):324-327.
1. Goldhaber JI, Weiss JN. Oxygen free radicals and cardiac
reperfusion abnormalities. Hypertension 1992;20:118-127.
2. Dhalla NS, Golfman L, Takeda S, et al. Evidence for the
role of oxidative stress in acute ischemic heart disease: a
brief review. Can J Cardiol 1999;15:587-593.
3. Halliwell B. Drug antioxidant effects. A basis for drug
selection? Drugs 1991;42:549-605.
4. Naik SR. Antioxidants and their role in biological
functions: an overview. Indian Drugs 2003;40:501-516.
5. Rona G, Chappel CI, Balazs T, Gaudry R. An infarct-like
myocardial lesion and other toxic manifestations produced
by isoproterenol in the rat. AMA Arch Pathol 1959;67:443-
455.
6. Huh H, Staba EJ. Botany and chemistry of Ginkgo biloba L.
J Herbs Spices Med Plants 1992;1:92-124.
7. Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective
and anti-oxidant effects of the terpenoid constituents
of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol
1997;29:733-742.
8. Naik SR, Pilgaonkar VW, Panda VS.
Neuropharmacological evaluation of Ginkgo biloba
phytosomes in rodents. Phytother Res 2006;20:901-905.
9. Naik SR, Panda VS. Antioxidant and hepatoprotective
effects of Ginkgo biloba phytosomes in carbon tetrachlorideinduced liver injury in rodents. Liver Int 2007;27:393-399.
10. Panda VS, Naik SR. Cardioprotective activity of Ginkgo
biloba phytosomes in isoproterenol-induced myocardial
necrosis in rats: a biochemical and histoarchitectural
evaluation. Exp Toxicol Pathol 2008;60:397-404.
11. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet
1992;340:1136-1139.
12. Naik SR, Pilgaonkar VW, Panda VS. Evaluation of
antioxidant activity of Ginkgo biloba phytosomes in rat
brain. Phytother Res 2006;20:1013-1016.
13. http://www.indena.com/pdf/phytosome.pdf [Accessed
April 1, 2009]
14. Gupta SK, Prakash J, Srivastava S. Validation of traditional
claim of Tulsi, Ocimum sanctum Linn as a medicinal plant.
Ind J Exp Biol 2002;40:765-773.
15. Mediratta PK, Dewan V, Bhattacharya SK, et al. Effect
of Ocimum sanctum Linn. on humoral immune responses.
Indian J Med Res 1988;87:384-386.
16. Sharma M, Kishore K, Gupta SK, et al. Cardioprotective
potential of Ocimum sanctum in isoproterenol induced
myocardial infarction in rats. Mol Cell Biochem
2001;225:75-83.
17. Arya DS, Nandave M, Ojha SK, et al. Myocardial salvaging
effects of Ocimum sanctum in experimental model of
myocardial necrosis: a haemodynamic, biochemical and
histoarchitectural assessment. Curr Sci 2006;91:667-672.
18. Uma Devi P, Ganasoundari A, Vrinda B, et al. Radiation
protection by the Ocimum flavonoids orientin and vicenin:
mechanisms of action. Radiat Res 2000;154:455-460.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein
measurement with the Folin phenol reagent. J Biol Chem
1951;193:265-275.
20. Ohkawa H, Ohishi N, Yagi K. Assay of lipid peroxides in
animal tissues by thiobarbituric acid reaction. Anal Biochem
1979;95:351-358.
21. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys
1959;82:70-77.
22. Sun M, Zigman S. An improved spectrophotometric
assay for superoxide dismutase based on epinephrine
autoxidation. Anal Biochem 1978;90:81-89.
23. Clairborne A. Catalase activity. In: Greenwald RA, ed. CRS
Handbook of Methods in Oxygen Radical Research. Boca
Raton, FL: CRS Press; 1991:283-284.
24. Rotruck JT, Pope AL, Ganther HE, et al. Selenium:
biochemical role as a component of glutathione peroxidase.
Science 1973;179:588-590.
25. Mohandas J, Marshall JJ, Duggin GG, et al. Low activities
of glutathione-related enzymes as factors in the genesis of
urinary bladder cancer. Cancer Res 1984;44:5086-5091.
26. Noronha-Dutra AA, Steen EM, Woolf N. The correlation
between catecholamine and lipid peroxidation induced
damage in heart cells. Basic Res Cardiol 1985;80:133-136.
27. Bhagat B, Sullivan JM, Fischer VW, et al. cAMP activity
and isoproterenol-induced myocardial injury in rats. Recent
Adv Stud Cardiac Struct Metab 1976;12:465-470.
28. Tappia PS, Hata T, Hozaima L, et al. Role of oxidative
stress in catecholamine-induced changes in cardiac
sarcolemmal Ca2+
 transport. Arch Biochem Biophys
2001;387:85-92.
29. Milei J, Nunez RG, Rapaport M. Pathogenesis of
isoproterenol-induced myocardial lesions: its relation to
human coagulative myocytolysis. Cardiology 1978;63:139-
151.
30. Meister A. New aspects of glutathione biochemistry and
transport – selective alteration of glutathione metabolism.
Nutr Rev 1984;42:397-410.
31. Townsend DM, Tew KD, Tapiero H. The importance
of glutathione in human disease. Biomed Pharmacother
2003;57:144-155.
32. Ji LL, Stratman FW, Lardy HA. Antioxidant enzyme
systems in rat liver and skeletal muscle. Influences of
selenium deficiency, chronic training, and acute exercise.
Arch Biochem Biophys 1988;263:150-160.
33. Tosaki A, Engelman DT, Pali T, et al. Ginkgo biloba extract
(EGb-761) improves postischemic function in isolated
preconditioned working rat hearts. Coron Artery Dis
1994;5:443-450.
34. Robak J, Gryglewski RJ. Flavonoids are scavengers of
superoxide anions. Biochem Pharmacol 1988;37:837-841.
[1] Lachance PA, Nakat Z, Jeong WS. 2001. Antioxidants: an
integrative approach. Nutrition. 17: 835–838.
[2] Bravo L. 1998. Polyphenols: chemistry, dietary sources,
metabolism, and nutritional significance. Nutrition
Reviews. 56: 317-333.
[3] Oktay M, Gulcin I, Kufrevioglu OI. 2003. Determination
of in vitro antioxidant activity of fennel (Foeniculum
vulgare) seed extract. Lebensmittel-Wissenchaft und
Technologie. 36: 263-271.
[4] Ames BN, Shigenaga MK, Hagen TM, 1993. Oxidants,
antioxidants, and the degenerative diseases of aging.
Proceedings of the National Academy of Science of
U.S.A. 90: 7915–7922.
[5] Aruoma  OI. 1998. Free radicals, oxidative stress, and
antioxidants in human health and disease. J Am Oil Chem
Soc. 75: 199–212.
[6] Amakura Y, Umino Y, Tsuji S, Ito H, Hatano T, Yoshida T,
and Y. Tonogai. 2002. Constituents and their antioxidativeeffects in eucalyptus leaf extract used as a natural food
additive. Food Chemistry. 77: 47–56.
[7] Da  Silva JMR, Darmon N, Fernandez Y, Mitjavila S.
1991. Oxygen free radical scavenger capacity in aqueous
models of different procyanidins from grape seeds.
Journal of Agriculture and Food Chemistry. 39: 1549–
52.
[8] Iriti M, Faoro F. 2004. Plant defense and human nutrition:
phenylpropanoids  on the menu. Current Topics in
Nutrition Research. 2: 47– 65.
[9] Paiva NL. 2000. An introduction to the biosynthesis of
chemicals used in plant–microbe communication. Journal
of Plant Growth Regulation. 19: 131–143.
[10] Chalker-Scott L. 1999. Environmental significance of
anthocyanins in plants stress responses. Photochemistry
and Photobiology. 70: 1–9.
[11] Winkel-Shirley B. 2002. Biosynthesis of flavonoids and
effects of stress. Current Opinion in Plant Biology. 5:
218–223.
1. Gordon MC, David JN. Naturan product drug discovery in the next millennium. Pharm Boil. 2001;39:8–17.
2. Wink M. Introduction Biochemistry, role and biotechnology of secondary products. In: Wink M, editor. Biochemistry of Secondary product Metabolism. Florida: CRC press, Boca Raton; 2000. pp. 1–16.
3. Cor JS, Beach JF, Blair A, Clark AJ, King J, Lee TB, et al. Disodium chromoglycate. Adv Drug Res. 1970;5:190–6.
4. Warrier PK. In: Indian Medicinal Plants. Longman O, editor. New Delhi: CBS publication; 1995. p. 168.
5. Biswas NP, Biswas AK. Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.) Environ Ecol. 2005;23:485–8.
6. Sen P. Therapeutic potential of Tulsi: From experience to facts. Drug News Views. 1993;1:15–21.
7. Gupta SK, Prakash J, Srivastav S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Exp Biol. 2002;40:765–73. [PubMed]
8. Chopra RN, Nayer SI, Chopra IC. New Delhi: CSIR; 1956. Glossary of Indian Medicinal plants.
9. Anbarasu K, Vijayalakshmi G. Improved shelf life of protein-rich tofu using Ocimum sanctum (tulsi) extracts to benefit Indian rural population. J Food Sci. 2007;72:M300–05. [PubMed]
10. Kelm MA, Nair MG, Strasburg GM, DeWitt DL. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 2000;7:7–13. [PubMed]
11. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. Urosolic acidinhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res. 2003;63:4375–83. [PubMed]
12. Jaggi RK, Madaan R, Singh B. Anticonvulsant potential of holy basil, Ocimum sanctum Linn., and its cultures. Indian J Exp Biol. 2003;41:1329–33. [PubMed]
13. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Radiation protection by the Ocimum flavonoids orientin and vicenin: Mechanisms of action. Radiat Res. 2000;154:455–60.
14. Narendhirakannan RT, Subramanian S, Kandaswamy M. Biochemical evaluation of antidiabetogenic properties of some commonly used Indian plants on streptozotocin-induced diabetes in experimental rats. Clin Exp Pharmacol Physiol. 2006;33:1150–7. [PubMed]
15. Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YH. Ocimum sanctum leaf extracts stimulate insulin secretion from perfusd pancreas, isolated islets and clonal pancreatic beta-cells. J Endocrinol. 2006;189:127–36. [PubMed]
16. Grover JK, Vats V, Yadav SS. Pterocarpus marsupium extract (Vijayasar) prevented the alteration in metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate. Diabetes Obes Metab. 2005;7:414–20. [PubMed]
17. Gholap S, Kar A. Hypoglycemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Pharmazie. 2004;59:876–8. [PubMed]
18. Vats V, Yadav SP, Grover JK. Ethanolic extract of Ocimum sanctum leaves partially attenuates sterptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol. 2004;90:155–60. [PubMed]
19. Rai V, Iyer U, Mani UV. Effect of Tulasi (Ocimum sanctum) leaf power supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats. Plant Foods Hum Nutr. 1997;50:9–16. [PubMed]
20. Chattopadhyay RR. Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Indian J Exp Biol. 1993;31:891–3. [PubMed]
21. Sood S, Narang D, Thomas MK, Gupta YK, Maulik SK. Effect of Ocimum sanctum Linn.on cardiac changes in rats subjected to chronic restraint stress. J Ethnopharmacol. 2006;108:423–7. [PubMed]
22. Sood S, Narang D, Dinda AK, Maulik SK. Chronic oral administration of Ocimum sanctum Linn.augments cardiac endogenous antioxidants and prevents isoproterenol-induced myocardial necrosis in rats. J Pharm Pharmacol. 2005;57:127–33. [PubMed]
23. Sharm M, Kishore K, Gupta SK, Joshi S, Arya DS. Cardiaprotective potential of Ocimum sanctum Linn in isoproterenol induced myocardial infraction in rats. Mol Cell Biochem. 2001;498:39–46.
24. Balanehru S, Nagarajan B. Intervention of adriamycin induced free radical damage. Biochem Int. 1992;28:735–44. [PubMed]
25. Shetty S, Udupa S, Udupa L, Somayaji N. Wound healing activity of Ocimum sanctum Linn with supportive role of antioxidant enzymes. Indian J Physiol Pharmacol. 2006;50:163–8. [PubMed]
26. Udupa SL, Shetty S, Udupa AL, Somayaji SN. Effect of Ocimum sanctum Linn.on normal and dexamethasone suppressed wound healing. Indian J Exp Biol. 2006;44:49–54. [PubMed]
27. Bhartiya US, Raut YS, Joseph LJ. Protective effect of Ocimum sanctum L after high-dose 131iodine exposure in mice: An in vivo study. Indian J Exp Biol. 2006;44:647–52. [PubMed]
28. Subramanian M, Chintalwar GJ, Chattopadhyay S. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Redox Rep. 2005;10:257–64. [PubMed]
29. Vrinda B, Uma Devi P. Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Mutat Res. 2001;498:39–46. [PubMed]
30. Devi PU, Ganasoundari A. Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Indian J Exp Biol. 1999;37:262–8. [PubMed]

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